FKBP6

Gene Symbol	FKBP6
Entrez Gene	8468
Alt Symbol	FKBP36
Species	Human
Gene Type	protein-coding
Description	FK506 binding protein 6, 36kDa
Other Description	36 kDa FKBP|PPIase FKBP6|immunophilin FKBP36|inactive PPIase FKBP6|inactive peptidyl-prolyl cis-trans isomerase FKBP6|peptidyl-prolyl cis-trans isomerase FKBP6|rotamase
Swissprots	Q9UDS0 O75344 B4DXT7 Q7Z4T4 G3V0I2
Accessions	CBH19283 EAW69684 EAW69685 EAW69686 O75344 AA909474 AF038847 AAC64249 AF447060 AAP97324 AK302121 BAG63499 AK310255 BC036817 AAH36817 BI461016 DB033483 DB450796 DB525126 EU176233 ABW03684 EU176537 ABW03338 GQ129339 ACT64473 GQ129340 ACT64474 XM_005250643 XP_005250700 XM_006716152 XP_006716215 XM_006716153 XP_006716216 XM_011516644 XP_011514946 NM_001135211 NP_001128683 NM_001281304 NP_001268233 NM_003602 NP_003593
Function	Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human FKBP6 full length protein - ab168000 from Abcam Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

Active human FKBP6 full length protein - ab95497 from Abcam Category Protein Prices $232.00, $883.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Active human FKBP6 full length protein - ab123536 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Human FKBP6 full length protein - ab166567 from Abcam Category Protein Source Wheat germ Species Human

FKBP6 Antibody Blocking Peptide - LS-E4597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FKBP6 Antibody Blocking Peptide - LS-E16044 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FKBP6 Protein - NBP1-44384 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Species Human

FKBP6 Partial Recombinant Protein - H00008468-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FKBP6 Recombinant Protein - H00008468-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

FKBP6 Recombinant Protein - P3508 from Novus Biologicals Category Protein Prices $549.00 Sizes 50 µg Species Human

FKBP6 Recombinant Protein - H00541473-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FKBP6-Antibody-C-term-Blocking-Peptide - BP16950b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FKBP6 Protein (OPPA02299) - OPPA02299 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg

Human FK506 Binding Protein 6 protein - orb90097 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg

FKBP6 Blocking Peptide - 33R-2850 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FKBP6 protein (His tag) - 80R-1324 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

FKBP6 - H00541473-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FKBP6 - H00541473-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FKBP6 / FKBP36 (1-327, His-tag) - AR09470PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

FKBP6 / FKBP36 (1-327, His-tag) - AR09470PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

FKBP6 / FKBP36 - H00008468-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

FKBP6 / FKBP36 - H00008468-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FKBP6 / FKBP36 - H00008468-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FKBP6 / FKBP36 - H00008468-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FKBP6 / FKBP36 - H00008468-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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