Gene Symbol |
Dntt
|
Entrez Gene |
21673
|
Alt Symbol |
Tdt
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
deoxynucleotidyltransferase, terminal
|
Other Description |
DNA nucleotidylexotransferase|terminal addition enzyme|terminal deoxynucleotidyl transferase
|
Swissprots |
Q99PD1 P09838 Q99PD0
|
Accessions |
AAK01196 EDL41849 P09838 AF316014 AAK07884 AF316015 AAK07885 AK039804 AK087978 BAC40071 AK088709 BAC40518 AK134009 BAE21978 BC027634 BC148334 AAI48335 BX639078 M26145 AAA74592 M26149 X04123 CAA27735 X68670 CAA48634 NM_001043228 NP_001036693 NM_009345 NP_033371
|
Function |
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
|
Subcellular Location |
Isoform TDT-S: Nucleus.
|
Top Pathways |
Hematopoietic cell lineage, Non-homologous end-joining
|