Gene Symbol | Dntt |
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Entrez Gene | 21673 |
Alt Symbol | Tdt |
Species | Mouse |
Gene Type | protein-coding |
Description | deoxynucleotidyltransferase, terminal |
Other Description | DNA nucleotidylexotransferase|terminal addition enzyme|terminal deoxynucleotidyl transferase |
Swissprots | Q99PD1 P09838 Q99PD0 |
Accessions | AAK01196 EDL41849 P09838 AF316014 AAK07884 AF316015 AAK07885 AK039804 AK087978 BAC40071 AK088709 BAC40518 AK134009 BAE21978 BC027634 BC148334 AAI48335 BX639078 M26145 AAA74592 M26149 X04123 CAA27735 X68670 CAA48634 NM_001043228 NP_001036693 NM_009345 NP_033371 |
Function | Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. |
Subcellular Location | Isoform TDT-S: Nucleus. |
Top Pathways | Hematopoietic cell lineage, Non-homologous end-joining |
TdT CRISPR/Cas9 KO Plasmid (m) - sc-423324 from Santa Cruz Biotechnology
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TdT HDR Plasmid (m) - sc-423324-HDR from Santa Cruz Biotechnology
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TdT Double Nickase Plasmid (m) - sc-423324-NIC from Santa Cruz Biotechnology
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TdT Double Nickase Plasmid (m2) - sc-423324-NIC-2 from Santa Cruz Biotechnology
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TdT CRISPR Activation Plasmid (m) - sc-423324-ACT from Santa Cruz Biotechnology
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TdT CRISPR Activation Plasmid (m2) - sc-423324-ACT-2 from Santa Cruz Biotechnology
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TdT Lentiviral Activation Particles (m) - sc-423324-LAC from Santa Cruz Biotechnology
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TdT Lentiviral Activation Particles (m2) - sc-423324-LAC-2 from Santa Cruz Biotechnology
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TdT siRNA (m) - sc-72058 from Santa Cruz Biotechnology
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TdT shRNA Plasmid (m) - sc-72058-SH from Santa Cruz Biotechnology
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TdT shRNA (m) Lentiviral Particles - sc-72058-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN30151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30151 from Sigma-Aldrich
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DNTT siRNA (Mouse) - CRM4076 from Cohesion Biosciences
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DNTT - MBS8205097 from MyBioSource
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shRNA set against Mouse DNTT (NM_009345.2) - SHH280065 from Creative biogene
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shRNA set against Mouse Dntt(NM_009345.2) - SHH012809 from Creative biogene
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shRNA set against Mouse Dntt(NM_001043228.1) - SHH012827 from Creative biogene
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DNTT shRNA Plasmid (Mouse) - CHM4076 from Cohesion Biosciences
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DNTT miRNA 3'UTR clone - MiUTR1M-03947 from Creative biogene
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DNTT miRNA 3'UTR clone - MiUTR1M-03948 from Creative biogene
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