| Gene Symbol |
ARHGAP29
|
| Entrez Gene |
9411
|
| Alt Symbol |
PARG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GTPase activating protein 29
|
| Other Description |
PTPL1-associated RhoGAP 1 (PARG1)|PTPL1-associated RhoGAP protein 1|rho GTPase-activating protein 29|rho-type GTPase-activating protein 29
|
| Swissprots |
Q5VYZ0 Q59H86 Q8TBI6 Q52LW3 Q6NVX2 O15463
|
| Accessions |
EAW73051 EAW73052 Q52LW3 AA326126 AB208873 BAD92110 AK092668 AK307733 AK310491 AL833445 AW295796 BC022483 AAH22483 BC037337 BC067839 AAH67839 BC093741 AAH93741 BC093767 AAH93767 BF115799 BI548487 BU507990 BX508890 CA454270 CB852768 U90920 AAB81012 XM_006711048 XP_006711111 XM_011542438 XP_011540740 XM_011542439 XP_011540741 XM_011542440 XP_011540742 NM_004815 NP_004806
|
| Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. {ECO:0000269|PubMed:9305890}.
|