Gene Symbol | ARHGAP29 |
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Entrez Gene | 9411 |
Alt Symbol | PARG1 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 29 |
Other Description | PTPL1-associated RhoGAP 1 (PARG1)|PTPL1-associated RhoGAP protein 1|rho GTPase-activating protein 29|rho-type GTPase-activating protein 29 |
Swissprots | Q5VYZ0 Q59H86 Q8TBI6 Q52LW3 Q6NVX2 O15463 |
Accessions | EAW73051 EAW73052 Q52LW3 AA326126 AB208873 BAD92110 AK092668 AK307733 AK310491 AL833445 AW295796 BC022483 AAH22483 BC037337 BC067839 AAH67839 BC093741 AAH93741 BC093767 AAH93767 BF115799 BI548487 BU507990 BX508890 CA454270 CB852768 U90920 AAB81012 XM_006711048 XP_006711111 XM_011542438 XP_011540740 XM_011542439 XP_011540741 XM_011542440 XP_011540742 NM_004815 NP_004806 |
Function | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
Tissue Specificity | Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. {ECO:0000269|PubMed:9305890}. |
ARHGAP29 CRISPR/Cas9 KO Plasmid (h) - sc-407394 from Santa Cruz Biotechnology
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ARHGAP29 HDR Plasmid (h) - sc-407394-HDR from Santa Cruz Biotechnology
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ARHGAP29 Double Nickase Plasmid (h) - sc-407394-NIC from Santa Cruz Biotechnology
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ARHGAP29 Double Nickase Plasmid (h2) - sc-407394-NIC-2 from Santa Cruz Biotechnology
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ARHGAP29 CRISPR Activation Plasmid (h) - sc-407394-ACT from Santa Cruz Biotechnology
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ARHGAP29 CRISPR Activation Plasmid (h2) - sc-407394-ACT-2 from Santa Cruz Biotechnology
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ARHGAP29 Lentiviral Activation Particles (h) - sc-407394-LAC from Santa Cruz Biotechnology
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ARHGAP29 Lentiviral Activation Particles (h2) - sc-407394-LAC-2 from Santa Cruz Biotechnology
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ARHGAP29 siRNA (h) - sc-78941 from Santa Cruz Biotechnology
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ARHGAP29 shRNA Plasmid (h) - sc-78941-SH from Santa Cruz Biotechnology
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ARHGAP29 shRNA (h) Lentiviral Particles - sc-78941-V from Santa Cruz Biotechnology
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PARG1 RNAi - H00009411-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3423 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3423 from Sigma-Aldrich
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ARHGAP29 siRNA (Human) - CRH6239 from Cohesion Biosciences
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ARHGAP29 - MBS8236948 from MyBioSource
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shRNA set against Human Arhgap29 (NM_004815.3) - SHH239478 from Creative biogene
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shRNA set against Human ARHGAP29(NM_004815.3) - SHG069983 from Creative biogene
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ARHGAP29 shRNA Plasmid (Human) - CHH6239 from Cohesion Biosciences
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ARHGAP29 miRNA 3'UTR clone - MiUTR1H-00521 from Creative biogene
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