| Gene Symbol |
LETMD1
|
| Entrez Gene |
25875
|
| Alt Symbol |
1110019O13Rik, HCCR-1, HCCR-2, HCCR1, HCRR-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LETM1 domain containing 1
|
| Other Description |
LETM1 domain-containing protein 1|cervical cancer 1 proto-oncogene protein p40|cervical cancer proto-oncogene 2 protein|regulator of TP53
|
| Swissprots |
Q9Y3X3 Q6X2E4 B3KXK7 Q96PK7 Q6X2E5 A6NER7 Q6P1Q0 Q9BY59 Q7L690 Q7L2G9 Q8WXW6
|
| Accessions |
EAW58166 EAW58167 EAW58168 EAW58169 EAW58170 EAW58171 EAW58172 Q6P1Q0 AF195651 AAK34885 AF315598 AAL26878 AF329277 AAL56993 AI313513 AK000639 AK057866 AK123080 AK126372 AK127540 BAG54519 AK225836 AK301898 BAH13580 AK301955 BAH13594 AK304707 BAH14243 AK315119 BAG37574 AL050286 CAB43387 AL079293 AY259835 AAP85624 AY259836 AAP85625 BC000395 AAH00395 BC019274 AAH19274 BC064943 AAH64943 BM549678 BM998643 BX343550 BX376670 DA682074 DC357852 HQ448111 ADQ32592 XM_006719335 XP_006719398 XM_006719336 XP_006719399 XM_006719338 XP_006719401 XM_006719339 XP_006719402 XM_006719340 XP_006719403 XM_011538161 XP_011536463 XM_011538162 XP_011536464 XM_011538163 XP_011536465 XM_011538164 XP_011536466 XM_011538165 XP_011536467 XM_011538166 XP_011536468 XM_011538167 XP_011536469 XR_944516 NM_001243689 NP_001230618 NM_001300765 NP_001287694 NM_015416 NP_056231 NR_045017 NR_045018 NR_045019 NR_045020 NM_001024668 NM_001024669 NM_001024670 NM_001024671
|
| Function |
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. {ECO:0000269|PubMed:12879013}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:17943721, ECO:0000269|PubMed:18045496}; Single-pass membrane protein {ECO:0000269|PubMed:17943721, ECO:0000269|PubMed:18045496}.
|
| Tissue Specificity |
Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix. {ECO:0000269|PubMed:12879013}.
|
![Western Blot: LETMD1 Overexpression Lysate (Adult Normal) [NBL1-12495] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LETMD1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6264_LETMD1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12495-img0002.jpg)