Gene Symbol | LPPR4 |
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Entrez Gene | 9890 |
Alt Symbol | LPR4, PHP1, PRG-1, PRG1 |
Species | Human |
Gene Type | protein-coding |
Description | lipid phosphate phosphatase-related protein type 4 |
Other Description | brain-specific phosphatidic acid phosphatase-like protein 1|plasticity related gene 1|plasticity-related gene 1 protein |
Swissprots | Q96MP0 Q5T9R9 Q8N3F1 Q7Z2D5 O75043 E7EPS1 Q86XQ5 |
Accessions | EAW72991 EAW72992 Q7Z2D5 AB007924 BAA32300 AF357013 AAO85400 AF541281 AAP57770 AK291369 BAF84058 AK300361 BAG62101 AL834390 CAD39052 AY304518 AAP72155 BC041386 AAH41386 BC042963 AAH42963 BC148348 AAI48349 XM_011542498 XP_011540800 NM_014839 NP_055654 NM_001166252 NP_001159724 |
Function | Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. {ECO:0000269|PubMed:12730698}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Specifically expressed in neurons. {ECO:0000269|PubMed:12730698}. |
LPPR4 CRISPR/Cas9 KO Plasmid (h) - sc-409758 from Santa Cruz Biotechnology
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LPPR4 HDR Plasmid (h) - sc-409758-HDR from Santa Cruz Biotechnology
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LPPR4 Double Nickase Plasmid (h) - sc-409758-NIC from Santa Cruz Biotechnology
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LPPR4 Double Nickase Plasmid (h2) - sc-409758-NIC-2 from Santa Cruz Biotechnology
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LPPR4 CRISPR Activation Plasmid (h) - sc-409758-ACT from Santa Cruz Biotechnology
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LPPR4 CRISPR Activation Plasmid (h2) - sc-409758-ACT-2 from Santa Cruz Biotechnology
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LPPR4 Lentiviral Activation Particles (h) - sc-409758-LAC from Santa Cruz Biotechnology
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LPPR4 Lentiviral Activation Particles (h2) - sc-409758-LAC-2 from Santa Cruz Biotechnology
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LPPR4 siRNA (h) - sc-78869 from Santa Cruz Biotechnology
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LPPR4 shRNA Plasmid (h) - sc-78869-SH from Santa Cruz Biotechnology
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LPPR4 shRNA (h) Lentiviral Particles - sc-78869-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU089851 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0308 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0309 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12663 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12663 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11596 from Sigma-Aldrich
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LPPR4 siRNA (Human) - CRH6636 from Cohesion Biosciences
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shRNA set against Human LPPR4 (NM_014839.4) - SHH333667 from Creative biogene
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Human LPPR4 siRNA - orb267138 from Biorbyt
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LPPR4 shRNA Plasmid (Human) - CHH6636 from Cohesion Biosciences
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