| Gene Symbol |
KRTAP5-9
|
| Entrez Gene |
3846
|
| Alt Symbol |
KRN1, KRTAP5-1, KRTAP5.9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 5-9
|
| Other Description |
UHS KerA|UHS keratin A|keratin, cuticle, ultrahigh sulfur 1|keratin, cuticle, ultrahigh sulphur 1|keratin, ultra high-sulfur matrix protein A|keratin-associated protein 5-9|keratin-associated protein 5.9|ultrahigh sulfur keratin-associated protein 5.9
|
| Swissprots |
P26371 Q3MIP8 Q14564
|
| Accessions |
CAA07189 CAA39005 P26371 AB126078 BAD20205 BC069531 AAH69531 BC101744 AAI01745 DB339866 HQ448422 ADQ32902 X63755 CAA45283 NM_005553 NP_005544
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles. {ECO:0000269|PubMed:15144888}.
|