| Gene Symbol |
ERRFI1
|
| Entrez Gene |
54206
|
| Alt Symbol |
GENE-33, MIG-6, MIG6, RALT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ERBB receptor feedback inhibitor 1
|
| Other Description |
mitogen-inducible gene 6 protein|receptor-associated late transducer
|
| Swissprots |
Q9NTG9 Q9UJM3 Q9UD05 B2RDX9
|
| Accessions |
AFM52327 EAW71592 EAW71593 EAW71594 Q9UJM3 AJ276373 CAC20426 AK027830 AK096149 BAG53220 AK315718 BAG38076 AL137274 CAB70672 BC012839 BC025337 AAH25337 DB033666 DQ892137 ABM83063 DQ895331 ABM86257 XM_005263477 XP_005263534 XM_006710697 XP_006710760 XM_011541596 XP_011539898 NM_018948 NP_061821
|
| Function |
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:7641805}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity). {ECO:0000250}.
|