SUFU

Gene Symbol SUFU
Entrez Gene 51684
Alt Symbol PRO1280, SUFUH, SUFUXL
Species Human
Gene Type protein-coding
Description suppressor of fused homolog (Drosophila)
Other Description suppressor of fused homolog
Swissprots Q9UMX1 Q9NZ07 Q7LCP7 Q9UHK2 Q9UMY0 Q9UHM8 Q9NT90
Accessions AAM08947 EAW49681 EAW49682 EAW49683 EAW49684 Q9UMX1 AF144231 AAF23890 AF159447 AAF23893 AF172319 AAD51655 AF175770 AAD50501 AF222345 AAF35866 AK307370 AK311503 AK312319 BAG35241 AL137465 CAB70752 AY358550 AAQ88914 BC013291 AAH13291 DA248208 DQ892586 ABM83512 DQ895804 ABM86730 XM_011539858 XP_011538160 XM_011539859 XP_011538161 XM_011539860 XP_011538162 XM_011539861 XP_011538163 XM_011539862 XP_011538164 XM_011539863 XP_011538165 XM_011539864 XP_011538166 NM_001178133 NP_001171604 NM_016169 NP_057253
Function Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required f
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in fetal brain, lung and kidney. {ECO:0000269|PubMed:10559945, ECO:0000269|PubMed:10564661}.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma

SUFU (C81H7) Rabbit mAb - 2522 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C81H7
Western blot analysis of total cell lysates from HeLa, COS and NIH/3T3 cells using SUFU (C81H7) Rabbit mAb.

SUFU (C54G2) Rabbit mAb - 2520 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C54G2
Western blot analysis of total cell lysates from various cell types using SUFU (C54G2) Rabbit mAb.

Su(fu) (C-15) - sc-10933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Su(fu) (C-15): sc-10933. Western blot analysis of Su(fu) expression in C32 (A) and IMR-32 (B) whole cell lysates.

Su(fu) (M-15) - sc-10934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Su(fu) (M-15): sc-10934. Western blot analysis of Su(fu) expression in IMR-32 whole cell lysate.

Su(fu) (H-300) - sc-28847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Su(fu) (H-300): sc-28847. Western blot analysis of Su(fu) expression in C32 (A) and SK-N-SH (B) whole cell lysates.

Su(fu) (F-4) - sc-137014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Su(fu) (F-4): sc-137014. Western blot analysis of Su(fu) expression in IMR-32 (A), SK-N-SH (B), EOC 20 (C) and C6 (D) whole cell lysates.

Anti-Suppressor of Fused (phospho S342) antibody - ab104741 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Suppressor of Fused antibody - ab118596 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118596, at 7.5 µg/ml, staining Suppressor of Fused in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry.

Anti-Suppressor of Fused antibody - ab114979 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab114979, used for IP at 3 µg/mg lysate, staining Suppressor of Fused in HeLa whole cell lysate (1 mg for IP, 20% of IP loaded). Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-Suppressor of Fused antibody [EP1207Y] - ab52913 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1207Y
Anti-Suppressor of Fused antibody [EP1207Y] (ab52913) at 1/200 dilution + LnCaP cell lysate at 10 µgSecondaryGoat anti rabbit HRP antibody at 1/2000 dilution

Anti-SUFU Antibody (aa2-13) IHC-plus™ - LS-B5105 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SUFU antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5105 concentration 3.75 ug/ml.

Anti-SUFU Antibody (C-Terminus) IHC-plus™ - LS-B6811 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SUFU antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6811 concentration 5 ug/ml.

Anti-SUFU Antibody (phospho-Ser342) - LS-C205315 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SUFU Antibody (C-Terminus) - LS-C209994 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-SUFU Antibody (Internal) - LS-C209996 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-SUFU Antibody (aa325-375) - LS-C289085 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SUFU Antibody (aa434-484) - LS-C289086 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SUFU Antibody - LS-C334926 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SUFU antibody.

Anti-SUFU Antibody (aa35-84) - LS-C109732 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SUFU antibody LS-C109732 Western blot of HepG2 cell lysate.

Anti-SUFU Antibody (aa215-264) - LS-C109731 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SUFU antibody LS-C109731 Western blot of PANC1 cell lysate.

Anti-SUFU Antibody (N-Terminus, clone EPR1206Y) - LS-C105384 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1206Y
IHC of paraffin-embedded human testis using anti-SuFu antibody (LS-C105384).

Anti-SUFU Antibody (clone EP1207Y) - LS-C49865 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1207Y
IHC of paraffin-embedded human fetal kidneys using anti-SuFu antibody.

Suppressor of Fused Antibody - NBP2-20536 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Suppressor of Fused Antibody [NBP2-20536] - Sample (30 ug of whole cell lysate) A: Hela 10% SDS PAGE gel, diluted at 1:1000.

Suppressor of Fused Antibody - NBP1-87384 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Suppressor of Fused Antibody (1B2) - H00051684-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B2
Sandwich ELISA: Suppressor of Fused Antibody (1B2) [H00051684-M01] - Detection limit for recombinant GST tagged SUFU is approximately 0.1ng/ml as a capture antibody.
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