| Gene Symbol | IL6 |
|---|---|
| Entrez Gene | 102138971 |
| Alt Symbol | IL-6 |
| Species | Monkey |
| Gene Type | protein-coding |
| Description | interleukin 6 (interferon, beta 2) |
| Other Description | hypothetical protein|interleukin-6 |
| Swissprots | P79341 |
| Accessions | EHH52277 P79341 AB000554 BAA19148 XM_005550000 XP_005550057 XM_005550001 XP_005550058 XM_005550002 XP_005550059 XM_005550003 XP_005550060 |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |