| Gene Symbol | CAPN2 |
|---|---|
| Entrez Gene | 824 |
| Alt Symbol | CANP2, CANPL2, CANPml, mCANP |
| Species | Human |
| Gene Type | protein-coding |
| Description | calpain 2, (m/II) large subunit |
| Other Description | CANP 2|M-calpain|calcium-activated neutral proteinase 2|calpain 2, large [catalytic] subunit|calpain 2, large subunit|calpain M-type|calpain large polypeptide L2|calpain, large polypeptide L2|calpain-2 catalytic subunit|calpain-2 large subunit|millimolar-calpain |
| Swissprots | Q8WU26 A6NDG7 Q16738 E7ES58 Q9HBB1 B7ZA96 P17655 Q6PJT3 |
| Accessions | AAA52760 AAV80421 EAW93249 EAW93250 EAW93251 P17655 AB209855 BAD93092 AF261089 AAF99682 AI089162 AK023851 AK055046 AK056838 AK097247 BAG53441 AK124751 BAC85936 AK297800 BAG60139 AK303952 BAG64879 AK315179 BAG37620 AK316211 BAH14582 BC007686 AAH07686 BC011828 AAH11828 BC021303 AAH21303 DA448245 DQ893312 ABM84238 DQ893620 ABM84546 EU176804 ABW03605 M23254 AAA35645 XM_011544286 XP_011542588 NM_001146068 NP_001139540 NM_001748 NP_001739 |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). {ECO:0000269|PubMed:17650508}. |
| Subcellular Location | Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | Apoptosis, Focal adhesion, Alzheimer's disease, Protein processing in endoplasmic reticulum |