Gene Symbol | USPL1 |
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Entrez Gene | 10208 |
Alt Symbol | C13orf22, D13S106E, bA121O19.1 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase like 1 |
Other Description | SUMO-specific isopeptidase USPL1|highly charged protein|ubiquitin-specific peptidase-like protein 1 |
Swissprots | Q8IYE8 Q8IY30 Q5W0Q7 Q6AI45 Q14109 |
Accessions | CCQ43337 EAX08466 Q5W0Q7 AK057514 BAG51926 AK289826 BAF82515 AL832776 BC012594 BC036027 AAH36027 BC038103 AAH38103 BI752017 CR627370 CAH10469 X59131 CAA41848 XM_005266213 XP_005266270 XM_005266214 XP_005266271 XM_006719751 XP_006719814 XM_011534862 XP_011533164 NM_005800 NP_005791 |
Function | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation. {ECO:0000269|PubMed:22878415}. |
Subcellular Location | Nucleus, Cajal body {ECO:0000269|PubMed:22878415}. |
USPL1 CRISPR/Cas9 KO Plasmid (h) - sc-408809 from Santa Cruz Biotechnology
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USPL1 HDR Plasmid (h) - sc-408809-HDR from Santa Cruz Biotechnology
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USPL1 Double Nickase Plasmid (h) - sc-408809-NIC from Santa Cruz Biotechnology
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USPL1 Double Nickase Plasmid (h2) - sc-408809-NIC-2 from Santa Cruz Biotechnology
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USPL1 CRISPR Activation Plasmid (h) - sc-408809-ACT from Santa Cruz Biotechnology
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USPL1 CRISPR Activation Plasmid (h2) - sc-408809-ACT-2 from Santa Cruz Biotechnology
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USPL1 Lentiviral Activation Particles (h) - sc-408809-LAC from Santa Cruz Biotechnology
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USPL1 Lentiviral Activation Particles (h2) - sc-408809-LAC-2 from Santa Cruz Biotechnology
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USPL1 siRNA (h) - sc-76875 from Santa Cruz Biotechnology
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USPL1 shRNA Plasmid (h) - sc-76875-SH from Santa Cruz Biotechnology
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USPL1 shRNA (h) Lentiviral Particles - sc-76875-V from Santa Cruz Biotechnology
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USPL1 RNAi - H00010208-R01 from Novus Biologicals
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MISSION® esiRNA - EHU040891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22609 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22609 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00392 from Sigma-Aldrich
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USPL1 siRNA (Human) - CRH6897 from Cohesion Biosciences
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USPL1 - MBS8226147 from MyBioSource
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shRNA set against Human USP (NM_005800.4) - SHH441188 from Creative biogene
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Human USPL1 siRNA - orb267399 from Biorbyt
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USPL1 shRNA Plasmid (Human) - CHH6897 from Cohesion Biosciences
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USPL1 miRNA 3'UTR clone - MiUTR3H-15153 from Creative biogene
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