DIAPH1

Gene Symbol	DIAPH1
Entrez Gene	1729
Alt Symbol	DFNA1, DIA1, DRF1, LFHL1, hDIA1
Species	Human
Gene Type	protein-coding
Description	diaphanous-related formin 1
Other Description	diaphanous homolog 1|diaphanous-related formin-1|protein diaphanous homolog 1
Swissprots	Q59FH8 B7ZKW2 O60610 Q17RN4 A6NF18 Q9UC76 E9PEZ2
Accessions	EAW61919 EAW61920 O60610 AB209482 BAD92719 AF051782 AAC05373 AK023345 BAB14533 AK057994 AK094264 AK301195 BAG62775 AK304291 BAG65149 AK307822 AL050086 AY007129 AY360322 AAQ64023 AY363395 AAQ63049 BC007411 AAH07411 BC117257 AAI17258 BC143413 AAI43414 BC143414 BQ945734 BT007318 AAP35982 DA593734 DQ067452 AAZ23039 DQ067453 AAZ23040 XM_005268384 XP_005268441 XM_011537572 XP_011535874 XM_011537573 XP_011535875 NM_001079812 NP_001073280 NM_005219 NP_005210
Function	Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membr
Subcellular Location	Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells.
Tissue Specificity	Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea.
Top Pathways	Focal adhesion, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DIAPH1 protein fragment - ab158283 from Abcam Category Protein Source Wheat germ Species Human

DIAPH1 Antibody Blocking Peptide - LS-E23306 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIAPH1 Antibody Blocking Peptide - LS-E26894 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DIAPH1 Protein - H00001729-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DIAPH1 blocking peptide - GTX88212-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

CYB5R3 protein (His tag) - 80R-2122 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

DIAPH1 Peptide - AC21-1727-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DIAPH1 - H00001729-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DIAPH1 - H00001729-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DIAPH1 Peptide - 42-285P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Mouse

DIAP1 fusion protein - ag17023 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DIAP1 fusion protein - Ag14523 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Diaphanous Homolog 1 (DIAPH1) - RPJ265Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Diaphanous Homolog 1 (DIAPH1) - RPJ265Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protein diaphanous homolog 1(DIAPH1) ,partial - CSB-YP006890HU CSB-EP006890HU CSB-BP006890HU CSB-MP006890HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Diaphanous Homolog 1 Protein (Recombinant) - abx168221 from Abbexa Category Protein Source Human Species Human

DIAPH1 (transcript variant 2) - TP313517 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DIAPH1 (transcript variant 1) - TP316318 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DIAPH1, Peptide - MBS426276 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

DIAPH1 Recombinant Protein Antigen - NBP1-85246PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DIAPH1-Blocking-Peptide-N-term - BP20655a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DIAPH1 Peptide, Human - M34GP04301H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Diaphanous Homolog 1 (DIAPH1) - RPU53250 from Biomatik Category Protein Prices $194.00, $396.00, $605.00, $721.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

Diaphanous Homolog 1, Recombinant Protein - MBS2031197 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Protein diaphanous homolog 1 (DIAPH1), partial, Recombinant Protein - MBS1062528 from MyBioSource Category Protein Prices $500.00, $665.00, $670.00, $730.00, $825.00, $900.00, $1,015.00, $1,025.00, $1,035.00, $1,060.00, $1,505.00, $1,540.00, $1,625.00, $2,020.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Yeast), 500 µg (E-Coli), 50 µg (Baculovirus), 200 µg (Yeast), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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