DIAPH1
| Gene Symbol | DIAPH1 |
|---|---|
| Entrez Gene | 1729 |
| Alt Symbol | DFNA1, DIA1, DRF1, LFHL1, hDIA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diaphanous-related formin 1 |
| Other Description | diaphanous homolog 1|diaphanous-related formin-1|protein diaphanous homolog 1 |
| Swissprots | Q59FH8 B7ZKW2 O60610 Q17RN4 A6NF18 Q9UC76 E9PEZ2 |
| Accessions | EAW61919 EAW61920 O60610 AB209482 BAD92719 AF051782 AAC05373 AK023345 BAB14533 AK057994 AK094264 AK301195 BAG62775 AK304291 BAG65149 AK307822 AL050086 AY007129 AY360322 AAQ64023 AY363395 AAQ63049 BC007411 AAH07411 BC117257 AAI17258 BC143413 AAI43414 BC143414 BQ945734 BT007318 AAP35982 DA593734 DQ067452 AAZ23039 DQ067453 AAZ23040 XM_005268384 XP_005268441 XM_011537572 XP_011535874 XM_011537573 XP_011535875 NM_001079812 NP_001073280 NM_005219 NP_005210 |
| Function | Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membr |
| Subcellular Location | Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells. |
| Tissue Specificity | Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea. |
| Top Pathways | Focal adhesion, Regulation of actin cytoskeleton |
Dia 1 CRISPR/Cas9 KO Plasmid (h) - sc-401929 from Santa Cruz Biotechnology
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Dia 1 HDR Plasmid (h) - sc-401929-HDR from Santa Cruz Biotechnology
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Dia 1 Double Nickase Plasmid (h) - sc-401929-NIC from Santa Cruz Biotechnology
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Dia 1 Double Nickase Plasmid (h2) - sc-401929-NIC-2 from Santa Cruz Biotechnology
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Dia 1 CRISPR Activation Plasmid (h) - sc-401929-ACT from Santa Cruz Biotechnology
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Dia 1 CRISPR Activation Plasmid (h2) - sc-401929-ACT-2 from Santa Cruz Biotechnology
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Dia 1 Lentiviral Activation Particles (h) - sc-401929-LAC from Santa Cruz Biotechnology
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Dia 1 Lentiviral Activation Particles (h2) - sc-401929-LAC-2 from Santa Cruz Biotechnology
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Dia 1 siRNA (h) - sc-35190 from Santa Cruz Biotechnology
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Dia 1 shRNA Plasmid (h) - sc-35190-SH from Santa Cruz Biotechnology
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Dia 1 shRNA (h) Lentiviral Particles - sc-35190-V from Santa Cruz Biotechnology
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DIAPH1 RNAi - H00001729-R02 from Novus Biologicals
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MISSION® esiRNA - EHU109471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7230 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7230 from Sigma-Aldrich
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DIAPH1 siRNA (Human) - CRH1198 from Cohesion Biosciences
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DIAPH1 RNAi - H00001729-R01 from Novus Biologicals
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DIAPH1 - MBS8234656 from MyBioSource
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Dia 1 CRISPR/Cas9 KO Plasmid (h2) - sc-401929-KO-2 from Santa Cruz Biotechnology
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Dia 1 HDR Plasmid (h2) - sc-401929-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DIAPH1 (NM_005219.4) - SHH278029 from Creative biogene
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Human DIAPH1 siRNA - orb261700 from Biorbyt
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DIAPH1 shRNA Plasmid (Human) - CHH1198 from Cohesion Biosciences
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DIAPH1 miRNA 3'UTR clone - MiUTR3H-04677 from Creative biogene
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DIAPH1 miRNA 3'UTR clone - MiUTR3H-04678 from Creative biogene
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