Gene Symbol | SLC39A14 |
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Entrez Gene | 23516 |
Alt Symbol | LZT-Hs4, NET34, ZIP14, cig19 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 39 (zinc transporter), member 14 |
Other Description | LIV-1 subfamily of ZIP zinc transporter 4|ZIP-14|Zrt-, Irt-like protein 14|solute carrier family 39 (metal ion transporter), member 14|solute carrier family 39 member 14|zinc transporter ZIP14|zrt- and Irt-like protein 14 |
Swissprots | A6NH98 Q15043 D3DSR4 B4DIW3 Q96BB3 Q6ZME8 B6EU88 |
Accessions | EAW63680 EAW63681 EAW63682 EAW63683 Q15043 AA181885 AF026940 AK172810 BAD18780 AK295807 BAG58625 BC000068 BC015770 AAH15770 BX648538 D31887 BAA06685 DC323208 DC423882 JF432188 ADZ15405 XM_005273463 XP_005273520 XM_005273465 XP_005273522 XM_005273466 XP_005273523 XM_006716323 XP_006716386 XM_006716324 XP_006716387 XM_011544477 XP_011542779 XM_011544478 XP_011542780 NM_001128431 NP_001121903 NM_001135153 NP_001128625 NM_001135154 NP_001128626 NM_015359 NP_056174 |
Function | May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. {ECO:0000250, ECO:0000269|PubMed:15642354}. |
Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae. |
Tissue Specificity | Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes. {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:7584044}. |
ZIP14 CRISPR/Cas9 KO Plasmid (h) - sc-411756 from Santa Cruz Biotechnology
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ZIP14 HDR Plasmid (h) - sc-411756-HDR from Santa Cruz Biotechnology
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ZIP14 Double Nickase Plasmid (h) - sc-411756-NIC from Santa Cruz Biotechnology
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ZIP14 Double Nickase Plasmid (h2) - sc-411756-NIC-2 from Santa Cruz Biotechnology
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ZIP14 CRISPR Activation Plasmid (h) - sc-411756-ACT from Santa Cruz Biotechnology
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ZIP14 CRISPR Activation Plasmid (h2) - sc-411756-ACT-2 from Santa Cruz Biotechnology
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ZIP14 Lentiviral Activation Particles (h) - sc-411756-LAC from Santa Cruz Biotechnology
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ZIP14 Lentiviral Activation Particles (h2) - sc-411756-LAC-2 from Santa Cruz Biotechnology
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ZIP14 siRNA (h) - sc-77569 from Santa Cruz Biotechnology
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ZIP14 shRNA Plasmid (h) - sc-77569-SH from Santa Cruz Biotechnology
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ZIP14 shRNA (h) Lentiviral Particles - sc-77569-V from Santa Cruz Biotechnology
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SLC39A14 RNAi - H00023516-R01 from Novus Biologicals
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MISSION® esiRNA - EHU065141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19619 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19619 from Sigma-Aldrich
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SLC39A14 siRNA (Human) - CRH8322 from Cohesion Biosciences
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SLC39A14 - MBS8212278 from MyBioSource
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shRNA set against Human SLC39A14 (NM_015359.4) - SHH411112 from Creative biogene
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Human SLC39A14 siRNA - orb268824 from Biorbyt
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SLC39A14 shRNA Plasmid (Human) - CHH8322 from Cohesion Biosciences
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SLC39A14 miRNA 3'UTR clone - MiUTR3H-10186 from Creative biogene
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