| Gene Symbol |
Tbcb
|
| Entrez Gene |
66411
|
| Alt Symbol |
2410007D12Rik, AU041393, CG22, CKAPI, Ckap1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tubulin folding cofactor B
|
| Other Description |
cytoskeleton-associated protein 1|cytoskeleton-associated protein CKAPI|tubulin-folding cofactor B|tubulin-specific chaperone B
|
| Swissprots |
Q9D1E6 Q9DCZ6 Q9CWR6
|
| Accessions |
EDL24039 EDL24040 Q9D1E6 AK002316 BAB22009 AK003655 BAB22918 AK010438 BAB26939 AK178194 AK183833 AK188411 AK214432 BC010684 AAH10684 BQ445322 XM_011250672 XP_011248974 NM_025548 NP_079824
|
| Function |
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. {ECO:0000250, ECO:0000269|PubMed:17184771, ECO:0000269|PubMed:17217416}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17217416}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17217416}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
|
| Tissue Specificity |
Widely expressed with highest levels in brain. Broadly distributed throughout the neonate brain but restricted mainly to ependymary cells in the adult brain where it is concentrated in the cilia. {ECO:0000269|PubMed:17217416}.
|
