Gene Symbol | KANSL1 |
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Entrez Gene | 284058 |
Alt Symbol | CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1 |
Species | Human |
Gene Type | protein-coding |
Description | KAT8 regulatory NSL complex subunit 1 |
Other Description | MLL1/MLL complex subunit KANSL1|MSL1 homolog 1|NSL complex protein NSL1|centromere protein 36|male-specific lethal 1 homolog|non-specific lethal 1 homolog |
Swissprots | Q6AW85 Q9BRH0 Q7Z3B3 Q9NTE7 Q9ULF3 Q8IYH1 A8K5E4 Q9UFT0 |
Accessions | CAD34785 EAW93576 EAW93577 Q7Z3B3 AB033093 BAA86581 AI253068 AK094946 BAG52961 AK291259 BAF83948 AK310569 AL117476 CAB55949 AL137317 CAB70694 AM392814 CAL37692 AM393686 CAL38562 BC035892 AAH35892 BC098376 AAH98376 BX538006 CAD97958 BX648760 CAH10565 DA010621 XM_005257232 XP_005257289 XM_005257233 XP_005257290 XM_005275644 XP_005275701 XM_005275645 XP_005275702 XM_006721823 XP_006721886 XM_006721824 XP_006721887 XM_011524628 XP_011522930 XM_011524629 XP_011522931 XM_011524630 XP_011522932 XM_011524631 XP_011522933 XM_011524632 XP_011522934 XM_011546340 XP_011544642 XM_011546341 XP_011544643 XM_011546342 XP_011544644 XM_011546343 XP_011544645 XM_011546344 XP_011544646 XM_011547471 XP_011545773 XM_011547472 XP_011545774 XM_011547473 XP_011545775 XM_011547474 XP_011545776 XM_011547475 XP_011545777 NM_001193465 NP_001180394 NM_001193466 NP_001180395 NM_015443 NP_056258 |
Function | As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20018852}. Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. |
Tissue Specificity | Expressed in the brain. {ECO:0000269|PubMed:11641718}. |
KIAA1267 CRISPR/Cas9 KO Plasmid (h) - sc-406711 from Santa Cruz Biotechnology
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KIAA1267 HDR Plasmid (h) - sc-406711-HDR from Santa Cruz Biotechnology
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KIAA1267 Double Nickase Plasmid (h) - sc-406711-NIC from Santa Cruz Biotechnology
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KIAA1267 Double Nickase Plasmid (h2) - sc-406711-NIC-2 from Santa Cruz Biotechnology
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KIAA1267 CRISPR Activation Plasmid (h) - sc-406711-ACT from Santa Cruz Biotechnology
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KIAA1267 CRISPR Activation Plasmid (h2) - sc-406711-ACT-2 from Santa Cruz Biotechnology
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KIAA1267 Lentiviral Activation Particles (h) - sc-406711-LAC from Santa Cruz Biotechnology
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KIAA1267 Lentiviral Activation Particles (h2) - sc-406711-LAC-2 from Santa Cruz Biotechnology
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KIAA1267 siRNA (h) - sc-93782 from Santa Cruz Biotechnology
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KIAA1267 shRNA Plasmid (h) - sc-93782-SH from Santa Cruz Biotechnology
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KIAA1267 shRNA (h) Lentiviral Particles - sc-93782-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11117 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11117 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09741 from Sigma-Aldrich
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KANSL1 siRNA (Human) - CRJ6962 from Cohesion Biosciences
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KANSL1, siRNA - MBS8230767 from MyBioSource
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KANSL1 CRISPR/Cas9 KO Plasmid (h2) - sc-406711-KO-2 from Santa Cruz Biotechnology
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KANSL1 HDR Plasmid (h2) - sc-406711-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KIAA1267 (NM_015443.3) - SHH324727 from Creative biogene
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Human KANSL1 siRNA - orb277463 from Biorbyt
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KANSL1 shRNA Plasmid (Human) - CHJ6962 from Cohesion Biosciences
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KANSL1 miRNA 3'UTR clone - MiUTR3H-12451 from Creative biogene
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