| Gene Symbol |
Cnot3
|
| Entrez Gene |
232791
|
| Alt Symbol |
A930039N10Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 3
|
| Other Description |
CCR4-NOT transcription complex subunit 3|CCR4-associated factor 3
|
| Swissprots |
B2RUA7 Q8K0V4
|
| Accessions |
EDL31189 Q8K0V4 AK031165 AK031774 AK044755 AK046141 AK141718 AK172439 AK173003 BAD32281 AK198704 BC030332 AAH30332 BC053437 AAH53437 BC060684 BC141041 AAI41042 BQ748712 CV783268 XM_006539752 XP_006539815 XM_006539753 XP_006539816 XM_006539755 XP_006539818 XM_006539756 XP_006539819 XM_006539757 XP_006539820 XM_011250500 XP_011248802 XM_011250501 XP_011248803 NM_146176 NP_666288
|
| Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269|PubMed:21897366, ECO:0000269|PubMed:223
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:20133598}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Note=NANOS2 promotes its localization to P-body.
|
| Top Pathways |
RNA degradation
|