Cnot3

Gene Symbol Cnot3
Entrez Gene 232791
Alt Symbol A930039N10Rik
Species Mouse
Gene Type protein-coding
Description CCR4-NOT transcription complex, subunit 3
Other Description CCR4-NOT transcription complex subunit 3|CCR4-associated factor 3
Swissprots B2RUA7 Q8K0V4
Accessions EDL31189 Q8K0V4 AK031165 AK031774 AK044755 AK046141 AK141718 AK172439 AK173003 BAD32281 AK198704 BC030332 AAH30332 BC053437 AAH53437 BC060684 BC141041 AAI41042 BQ748712 CV783268 XM_006539752 XP_006539815 XM_006539753 XP_006539816 XM_006539755 XP_006539818 XM_006539756 XP_006539819 XM_006539757 XP_006539820 XM_011250500 XP_011248802 XM_011250501 XP_011248803 NM_146176 NP_666288
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269|PubMed:21897366, ECO:0000269|PubMed:223
Subcellular Location Nucleus {ECO:0000305|PubMed:20133598}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Note=NANOS2 promotes its localization to P-body.
Top Pathways RNA degradation

CNOT3 CRISPR/Cas9 KO Plasmid (m) - sc-433192 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 HDR Plasmid (m) - sc-433192-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 Double Nickase Plasmid (m) - sc-433192-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 Double Nickase Plasmid (m2) - sc-433192-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 CRISPR Activation Plasmid (m) - sc-433192-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 CRISPR Activation Plasmid (m2) - sc-433192-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 Lentiviral Activation Particles (m) - sc-433192-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 Lentiviral Activation Particles (m2) - sc-433192-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

CNOT3 siRNA (m) - sc-72940 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CNOT3 shRNA Plasmid (m) - sc-72940-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CNOT3 shRNA (m) Lentiviral Particles - sc-72940-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU024421 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN28971 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28971 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CNOT3 siRNA (Mouse) - CRN3017 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CNOT3 - MBS8213542 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse CNOT3 (NM_146176.3) - SHH266441 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse CNOT3 siRNA - orb292492 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CNOT3 shRNA Plasmid (Mouse) - CHN3017 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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