Gene Symbol | ARL2BP |
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Entrez Gene | 23568 |
Alt Symbol | BART, BART1, RP66 |
Species | Human |
Gene Type | protein-coding |
Description | ADP-ribosylation factor-like 2 binding protein |
Other Description | ADP-ribosylation factor-like protein 2-binding protein|ARF-like 2-binding protein|ARL2-binding protein|Arf-like 2 binding protein BART1|binder of ARF2 protein 1|binder of Arl Two|binder of Arl2|retinitis pigmentosa 66 (autosomal recessive) |
Swissprots | B3KQJ5 Q504R0 Q9Y2Y0 |
Accessions | CAD88076 CAF86252 EAW82913 EAW82914 Q9Y2Y0 AF126062 AAD20633 AK075050 BAG52057 AK298758 BAG60900 AK311018 BC003087 AAH03087 BC094878 AAH94878 BF590083 XM_011522977 XP_011521279 NM_012106 NP_036238 |
Function | Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. {ECO:0000269|PubMed:18234692}. |
Subcellular Location | Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization. {ECO:0000250}. |
Tissue Specificity | Expressed in retina pigment epithelial cells (at protein level). Widely expressed. {ECO:0000269|PubMed:10488091, ECO:0000269|PubMed:23849777}. |
BART1 CRISPR/Cas9 KO Plasmid (h) - sc-411768 from Santa Cruz Biotechnology
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BART1 HDR Plasmid (h) - sc-411768-HDR from Santa Cruz Biotechnology
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BART1 Double Nickase Plasmid (h) - sc-411768-NIC from Santa Cruz Biotechnology
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BART1 Double Nickase Plasmid (h2) - sc-411768-NIC-2 from Santa Cruz Biotechnology
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BART1 CRISPR Activation Plasmid (h) - sc-411768-ACT from Santa Cruz Biotechnology
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BART1 CRISPR Activation Plasmid (h2) - sc-411768-ACT-2 from Santa Cruz Biotechnology
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BART1 Lentiviral Activation Particles (h) - sc-411768-LAC from Santa Cruz Biotechnology
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BART1 Lentiviral Activation Particles (h2) - sc-411768-LAC-2 from Santa Cruz Biotechnology
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BART1 siRNA (h) - sc-93111 from Santa Cruz Biotechnology
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BART1 shRNA Plasmid (h) - sc-93111-SH from Santa Cruz Biotechnology
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BART1 shRNA (h) Lentiviral Particles - sc-93111-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU026591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3487 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3487 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09359 from Sigma-Aldrich
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ARL2BP siRNA (Human) - CRH8368 from Cohesion Biosciences
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ARL2BP - MBS8216122 from MyBioSource
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shRNA set against Human ARL2BP (NM_012106.3) - SHH240182 from Creative biogene
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shRNA set against Human ARL2BP(NM_012106.3) - SHG072541 from Creative biogene
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ARL2BP shRNA Plasmid (Human) - CHH8368 from Cohesion Biosciences
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ARL2BP miRNA 3'UTR clone - MiUTR1H-00565 from Creative biogene
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