| Gene Symbol |
CENPN
|
| Entrez Gene |
55839
|
| Alt Symbol |
BM039, C16orf60, CENP-N, ICEN32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein N
|
| Other Description |
interphase centromere complex protein 32
|
| Swissprots |
D3DUK8 E7ES30 B3KN53 B4DJD1 E7ETS3 A8MZE6 Q9NZ83 Q96H22 C9JJM5 B4DPY7
|
| Accessions |
EAW95553 EAW95554 EAW95555 EAW95556 Q96H22 AF217515 AAF67626 AK023669 BAG51215 AK026313 AK296024 BAG58793 AK298554 BAG60749 AW085187 BC007334 AAH07334 BC008972 AAH08972 BC039021 BQ013821 HY167728 HY363272 HY374758 XM_006721236 XP_006721299 NM_001100624 NP_001094094 NM_001100625 NP_001094095 NM_001270473 NP_001257402 NM_001270474 NP_001257403 NM_018455 NP_060925
|
| Function |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
|