CENPN

Gene Symbol	CENPN
Entrez Gene	55839
Alt Symbol	BM039, C16orf60, CENP-N, ICEN32
Species	Human
Gene Type	protein-coding
Description	centromere protein N
Other Description	interphase centromere complex protein 32
Swissprots	D3DUK8 E7ES30 B3KN53 B4DJD1 E7ETS3 A8MZE6 Q9NZ83 Q96H22 C9JJM5 B4DPY7
Accessions	EAW95553 EAW95554 EAW95555 EAW95556 Q96H22 AF217515 AAF67626 AK023669 BAG51215 AK026313 AK296024 BAG58793 AK298554 BAG60749 AW085187 BC007334 AAH07334 BC008972 AAH08972 BC039021 BQ013821 HY167728 HY363272 HY374758 XM_006721236 XP_006721299 NM_001100624 NP_001094094 NM_001100625 NP_001094095 NM_001270473 NP_001257402 NM_001270474 NP_001257403 NM_018455 NP_060925
Function	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CENPN full length protein - ab163249 from Abcam Category Protein Source Wheat germ Species Human

Human CENPN full length protein - ab178480 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

CENPN / CENP-N Antibody Blocking Peptide - LS-E7639 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CENPN / CENP-N Antibody Blocking Peptide - LS-E20892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CENPN Recombinant Protein - H00055839-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CENPN-Antibody-C-term-Blocking-Peptide - BP4913b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CENPN Blocking Peptide - 33R-8430 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CENP-N - H00055839-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CENP-N - H00055839-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CENPN fusion protein - ag10219 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Centromere protein N(CENPN) - CSB-YP005217HU CSB-EP005217HU CSB-BP005217HU CSB-MP005217HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Centromere protein N (CENPN), Recombinant Protein - MBS1485640 from MyBioSource Category Protein Prices $1,100.00, $1,100.00, $1,330.00, $1,330.00, $1,740.00, $1,740.00, $2,205.00, $2,205.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CENPN-Antibody-Center-Blocking-Peptide - BP4913c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CENPN Peptide, Human - M34GP02974H from Creative Peptides Category Peptide Source Synthetic. Species Human

CENPN Recombinant Protein Antigen - NBP2-55538PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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