| Gene Symbol | TECR |
|---|---|
| Entrez Gene | 9524 |
| Alt Symbol | GPSN2, MRT14, SC2, TER |
| Species | Human |
| Gene Type | protein-coding |
| Description | trans-2,3-enoyl-CoA reductase |
| Other Description | glycoprotein, synaptic 2|synaptic glycoprotein SC2|very-long-chain enoyl-CoA reductase |
| Swissprots | Q6IBB2 Q9BWK3 O75350 Q9NZ01 Q9Y6P0 B2RD55 |
| Accessions | EAW84434 EAW84435 Q9NZ01 AF038958 AAC39872 AF038959 AAC39873 AF222742 AAF32373 AK001416 BAG50909 AK094087 BAG52813 AK299134 BAG61186 AK315412 BAG37802 BC000174 AAH00174 BC002425 AAH02425 BC005384 BC005952 AAH05952 BC007801 AAH07801 BC013881 AAH13881 BC034484 BG705196 BT007179 AAP35843 CR456892 CAG33173 DB491783 DQ891949 ABM82875 DQ895135 ABM86061 EU832830 ACE87841 GQ129437 ACT64571 XM_006722945 XP_006723008 XM_006722947 XP_006723010 XM_011528442 XP_011526744 NM_138501 NP_612510 NR_038103 NR_038104 NM_004868 |
| Function | Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:12482854}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}. |
| Tissue Specificity | Expressed in most tissues tested. Highly expressed in skeletal muscle. {ECO:0000269|PubMed:12482854}. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |