SPTAN1

Gene Symbol	SPTAN1
Entrez Gene	6709
Alt Symbol	EIEE5, NEAS, SPTA2
Species	Human
Gene Type	protein-coding
Description	spectrin, alpha, non-erythrocytic 1
Other Description	alpha-II spectrin\|alpha-fodrin\|fodrin alpha chain\|spectrin alpha chain, non-erythrocytic 1\|spectrin, non-erythroid alpha chain\|spectrin, non-erythroid alpha subunit
Swissprots	Q15324 Q9P0V0 Q5VXV5 Q7Z6M5 Q13813 Q16606 Q59EF1 Q5VXV6 Q13186
Accessions	AAF26672 EAW87805 EAW87806 EAW87807 EAW87808 EAW87809 EAW87810 EAW87811 EAW87812 EAW87813 Q13813 AB191262 BAD52438 AB209860 BAD93097 AK026484 AK126576 AK294753 BAG57892 AK300386 BAG62120 AK307676 AK309836 AK310696 AL110273 CAB53710 BC034956 BC051801 BC053521 AAH53521 BP200529 DC359079 J05243 AAA51790 M18627 AAA51702 M19725 AAA59904 M24773 AAA52468 U26396 AAB60364 U83867 AAB41498 X86901 CAA60503 XM_006717245 XP_006717308 XM_006717246 XP_006717309 XM_006717247 XP_006717310 XM_006717248 XP_006717311 XM_006717249 XP_006717312 XM_006717250 XP_006717313 XM_006717251 XP_006717314 XM_006717252 XP_006717315 XM_006717253 XP_006717316 XM_006717254 XP_006717317 NM_001130438 NP_001123910 NM_001195532 NP_001182461 NM_003127 NP_003118
Function	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.
Top Pathways	Tight junction

Cleaved α-Fodrin (Asp1185) Antibody - 2121 from Cell Signaling Technology

Prices	$287.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa cells, untreated or staurosporine-treated, using Cleaved alpha-Fodrin (Asp1185) Antibody (left) or alpha-Fodrin Antibody #2122 (right).

Alpha-Fodrin Antibody - 2122 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa cells, untreated or staurosporine-treated, using Cleaved alpha-Fodrin (Asp1185) Antibody #2121 (left) and alpha-Fodrin Antibody (right).

spectrin (RG/26) - sc-53444 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

spectrin (RG/26): sc-53444. Western blot analysis of spectrin expression in TF-1 (A), HEL 92.1.7 (B) and K-562 (C) whole cell lysates.

spectrin α II (B-2) - sc-376849 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

spectrin α II (B-2): sc-376849. Western blot analysis of spectrin α II expression in rat brain tissue extract (A) and TF-1 whole cell lysate (B).

spectrin α II (C-11) - sc-46696 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

spectrin α II (C-11): sc-46696. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

spectrin α II (C-20) - sc-7465 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

spectrin α II (C-20): sc-7465. Western blot analysis of spectrin α II expression in rat brain extract.

spectrin α II (C-3) - sc-48382 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

spectrin α II (C-3): sc-48382. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoskeletal localization.

spectrin α II (H-105) - sc-28270 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

spectrin α II (H-105): sc-28270. Immunofluorescence staining of normal mouse spleen frozen section showing cytoplasmic staining.

cleaved spectrin α II (h1479) - sc-23465 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

cleaved spectrin αII (h1186) - sc-23464 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Alpha Fodrin antibody - ab131609 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Alpha Fodrin antibody (ab131609) at 1/5000 dilution + Mouse brain lysate

Anti-Alpha Fodrin antibody - ab75284 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Alpha Fodrin antibody (ab75284) at 1/500 dilutionLane 1 : Extracts from HeLa cells treated with etoposide (25uM, 24hours)Lane 2 : Extracts from A549 cells treated with etoposide (25uM, 24hours)Lane 3 : Extracts from HeLa cells treated with etoposide (25uM, 24hours) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Alpha Fodrin antibody [D8B7] - ab11755 from Abcam

Prices	$401.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	D8B7

Anti-Alpha Fodrin antibody [EPR3016] - ab133342 from Abcam

Prices	$387.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3016

Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human colon tissue staining Alpha Fodrin with ab133342 at 1/10,000 dilution.

Anti-Alpha Fodrin antibody [EPR3017] - ab75755 from Abcam

Prices	$391.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3017

All lanes : Anti-Alpha Fodrin antibody [EPR3017] (ab75755) at 1/1000 dilutionLane 1 : HeLa cell lysate treated with CamptothecinLane 2 : HeLa cell lysateLane 3 : Jurkat treated with StaurosporineLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Alpha Fodrin antibody [EPR3017] (HRP) - ab199075 from Abcam

Prices	$425.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3017

All lanes : Anti-Alpha Fodrin antibody [EPR3017] (HRP) (ab199075) at 1/5000 dilutionLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 2 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-Alpha Fodrin antibody [EPR3830] - ab133320 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3830

All lanes : Anti-Alpha Fodrin antibody [EPR3830] (ab133320) at 1/10000 dilutionLane 1 : HeLa cell lysate + camptothecin Lane 2 : HeLa cell lysateLane 3 : Jurkat cell lysate + staurosporineLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Alpha Fodrin antibody [EPR3830] - ab92373 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3830

All lanes : Anti-Alpha Fodrin antibody [EPR3830] (ab92373)Lane 1 : HeLa + Camptothecin cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat + Staurosporine cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SPTAN1 / Alpha Fodrin Antibody (aa1950-2137) - LS-C292780 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant SPTAN1 / Alpha Fodrin.

Anti-SPTAN1 / Alpha Fodrin Antibody (aa1004-1181, FITC) - LS-C304727 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPTAN1 / Alpha Fodrin Antibody (aa1573-1742) - LS-C292778 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPTAN1 / Alpha Fodrin Antibody (aa595-783, FITC) - LS-C304738 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPTAN1 / Alpha Fodrin Antibody (Internal, clone EPR3830) - LS-C137899 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3830

IHC of paraffin-embedded human colon tissue using anti-Alpha Fodrin antibody.

Anti-SPTAN1 / Alpha Fodrin Antibody (aa1605-1806, FITC) - LS-C304728 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SPTAN1 / Alpha Fodrin Antibody (aa1571-1712, FITC) - LS-C305116 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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