| Gene Symbol |
AZIN1
|
| Entrez Gene |
51582
|
| Alt Symbol |
AZI, AZIA1, OAZI, OAZIN, ODC1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
antizyme inhibitor 1
|
| Other Description |
ornithine decarboxylase antizyme inhibitor
|
| Swissprots |
Q6IBQ7 O14977 Q96D20 A6NCD5
|
| Accessions |
EAW91851 EAW91852 EAW91853 O14977 AF070634 AAC25391 AI671875 AK095493 BAG53068 AK290516 BAF83205 AU280209 BC013420 AAH13420 BC019279 AAH19279 BC042404 BM716557 BT006858 AAP35504 CR456745 CAG33026 D88674 BAA23593 DB092816 DQ890724 ABM81650 DQ892205 ABM83131 DQ892206 ABM83132 DQ895400 ABM86326 XM_005250969 XP_005251026 XM_011517126 XP_011515428 XM_011517127 XP_011515429 XM_011517128 XP_011515430 NM_001301668 NP_001288597 NM_015878 NP_056962 NM_148174 NP_680479
|
| Function |
Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269|PubMed:17900240}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver.
|
![Western Blot: Antizyme inhibitor 1 Overexpression Lysate (Adult Normal) [NBL1-07873] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Antizyme inhibitor 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8091_Antizyme%2520inhibitor%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07873-img0002.jpg)