Gene Symbol | AZIN1 |
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Entrez Gene | 51582 |
Alt Symbol | AZI, AZIA1, OAZI, OAZIN, ODC1L |
Species | Human |
Gene Type | protein-coding |
Description | antizyme inhibitor 1 |
Other Description | ornithine decarboxylase antizyme inhibitor |
Swissprots | Q6IBQ7 O14977 Q96D20 A6NCD5 |
Accessions | EAW91851 EAW91852 EAW91853 O14977 AF070634 AAC25391 AI671875 AK095493 BAG53068 AK290516 BAF83205 AU280209 BC013420 AAH13420 BC019279 AAH19279 BC042404 BM716557 BT006858 AAP35504 CR456745 CAG33026 D88674 BAA23593 DB092816 DQ890724 ABM81650 DQ892205 ABM83131 DQ892206 ABM83132 DQ895400 ABM86326 XM_005250969 XP_005251026 XM_011517126 XP_011515428 XM_011517127 XP_011515429 XM_011517128 XP_011515430 NM_001301668 NP_001288597 NM_015878 NP_056962 NM_148174 NP_680479 |
Function | Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269|PubMed:17900240}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed in liver. |
OAZIN CRISPR/Cas9 KO Plasmid (h) - sc-412222 from Santa Cruz Biotechnology
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OAZIN HDR Plasmid (h) - sc-412222-HDR from Santa Cruz Biotechnology
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OAZIN Double Nickase Plasmid (h) - sc-412222-NIC from Santa Cruz Biotechnology
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OAZIN Double Nickase Plasmid (h2) - sc-412222-NIC-2 from Santa Cruz Biotechnology
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OAZIN CRISPR Activation Plasmid (h) - sc-412222-ACT from Santa Cruz Biotechnology
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OAZIN CRISPR Activation Plasmid (h2) - sc-412222-ACT-2 from Santa Cruz Biotechnology
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OAZIN Lentiviral Activation Particles (h) - sc-412222-LAC from Santa Cruz Biotechnology
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OAZIN Lentiviral Activation Particles (h2) - sc-412222-LAC-2 from Santa Cruz Biotechnology
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OAZIN siRNA (h) - sc-77594 from Santa Cruz Biotechnology
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OAZIN shRNA Plasmid (h) - sc-77594-SH from Santa Cruz Biotechnology
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OAZIN shRNA (h) Lentiviral Particles - sc-77594-V from Santa Cruz Biotechnology
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Antizyme inhibitor 1 RNAi - H00051582-R01 from Novus Biologicals
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Antizyme inhibitor 1 RNAi - H00051582-R02 from Novus Biologicals
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MISSION® esiRNA - EHU135121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3791 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12900 from Sigma-Aldrich
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AZIN1 siRNA (Human) - CRH9843 from Cohesion Biosciences
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AZIN1 - MBS8234694 from MyBioSource
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shRNA set against Human AZIN1 (NM_015878.4) - SHH244038 from Creative biogene
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shRNA set against Human AZIN1(NM_015878.4) - SHG087977 from Creative biogene
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AZIN1 shRNA Plasmid (Human) - CHH9843 from Cohesion Biosciences
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AZIN1 miRNA 3'UTR clone - MiUTR1H-00758 from Creative biogene
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