Gene Symbol | TTLL7 |
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Entrez Gene | 79739 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | tubulin tyrosine ligase-like family member 7 |
Other Description | testis development protein NYD-SP30|tubulin polyglutamylase TTLL7|tubulin tyrosine ligase-like family, member 7|tubulin--tyrosine ligase-like protein 7 |
Swissprots | Q6ZT98 Q5TAX8 Q9H5U4 Q86YS1 Q6P990 Q5TAX9 |
Accessions | EAW73251 EAW73252 Q6ZT98 AK026686 BAB15526 AK094174 AK126792 BAC86695 AK128604 BAC87524 AK225574 AY170843 AAO37763 BC028350 AAH28350 BC032829 BC048970 AAH48970 BC060878 AAH60878 BG718305 JF432361 ADZ15578 XM_005271208 XP_005271265 XM_005271211 XP_005271268 XM_011542155 XP_011540457 XM_011542156 XP_011540458 XM_011542157 XP_011540459 XM_011542158 XP_011540460 XM_011542159 XP_011540461 XR_946758 XR_946759 XR_946760 NM_024686 NP_078962 |
Function | Polyglutamylase which preferentially modifies beta- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon (By similarity). {ECO:0000250}. |
Tissue Specificity | Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum. {ECO:0000269|PubMed:16901895}. |
TTLL7 CRISPR/Cas9 KO Plasmid (h) - sc-413228 from Santa Cruz Biotechnology
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TTLL7 HDR Plasmid (h) - sc-413228-HDR from Santa Cruz Biotechnology
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TTLL7 Double Nickase Plasmid (h) - sc-413228-NIC from Santa Cruz Biotechnology
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TTLL7 Double Nickase Plasmid (h2) - sc-413228-NIC-2 from Santa Cruz Biotechnology
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TTLL7 CRISPR Activation Plasmid (h) - sc-413228-ACT from Santa Cruz Biotechnology
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TTLL7 CRISPR Activation Plasmid (h2) - sc-413228-ACT-2 from Santa Cruz Biotechnology
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TTLL7 Lentiviral Activation Particles (h) - sc-413228-LAC from Santa Cruz Biotechnology
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TTLL7 Lentiviral Activation Particles (h2) - sc-413228-LAC-2 from Santa Cruz Biotechnology
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TTLL7 siRNA (h) - sc-88086 from Santa Cruz Biotechnology
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TTLL7 shRNA Plasmid (h) - sc-88086-SH from Santa Cruz Biotechnology
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TTLL7 shRNA (h) Lentiviral Particles - sc-88086-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU072931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22205 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22205 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05518 from Sigma-Aldrich
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TTLL7 siRNA (Human) - CRJ2528 from Cohesion Biosciences
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TTLL7 - MBS8226222 from MyBioSource
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shRNA set against Human TTLL7 (NM_024686.4) - SHH437444 from Creative biogene
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TTLL7 shRNA Plasmid (Human) - CHJ2528 from Cohesion Biosciences
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TTLL7 miRNA 3'UTR clone - MiUTR1H-10865 from Creative biogene
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