RWDD3

Gene Symbol	RWDD3
Entrez Gene	25950
Alt Symbol	RSUME
Species	Human
Gene Type	protein-coding
Description	RWD domain containing 3
Other Description	RWD domain-containing protein 3|RWD domain-containing sumoylation enhancer|RWD-containing sumoylation enhancer
Swissprots	Q08AJ7 Q6FID3 Q9BX35 C9JI45 A6NP44 C9J9L7 A8K9F0 Q9Y3V2
Accessions	EAW73019 EAW73020 EAW73021 EAW73022 EAW73023 Q9Y3V2 AA336253 AA336662 AA825527 AK292665 BAF85354 AK292699 BAF85388 AK296476 BAG59117 AL050062 CAB43254 AM392773 CAL37651 AM393257 CAL38135 BC010936 BC016307 BC065813 BC125142 AAI25143 BU858771 BX537497 BX648581 CA454169 CN306675 CR533493 CAG38524 DC409838 NM_001128142 NP_001121614 NM_001199682 NP_001186611 NM_001278247 NP_001265176 NM_001278248 NP_001265177 NM_015485 NP_056300 NR_103483 NR_103484
Function	Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no
Subcellular Location	Nucleus {ECO:0000269|PubMed:17956732}. Cytoplasm {ECO:0000269|PubMed:17956732}. Note=Colocalizes with UBC9/UBE2I in nuclear spots.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in glioma tumors (at protein level). Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:17956732, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:23469069}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RWDD3 full length protein - ab132896 from Abcam Category Protein Source Wheat germ Species Human

RWDD3 peptide - ab117773 from Abcam Category Peptide

RWDD3 Antibody Blocking Peptide - LS-E30782 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RWDD3 Antibody Blocking Peptide - LS-E30781 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RWDD3 Antibody Blocking Peptide - LS-E21719 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RWDD3 Protein - H00025950-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RWDD3 Blocking Peptide - NBP1-76310PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RWDD3 Blocking Peptide - NBP1-76309PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RWDD3-Antibody-C-term-Blocking-Peptide - BP9363b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RWDD3 Peptide - GTX85245-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

RWDD3 Peptide - GTX85246-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

RWDD3 - H00025950-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RWDD3 - H00025950-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RWDD3 Peptide - 5409P from ProSci Category Peptide Species Human

RWDD3 Peptide - 5407P from ProSci Category Peptide Species Human

RWDD3 fusion protein - Ag18674 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RWDD3 fusion protein - ag18576 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RWDD3 (transcript variant 2) - TP325219 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RWDD3 Protein - NBP1-92360PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RWDD3 Peptide, Human - M34GP13704H from Creative Peptides Category Peptide Source Synthetic. Species Human

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