Gene Symbol | POLR2K |
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Entrez Gene | 5440 |
Alt Symbol | ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa |
Other Description | DNA directed RNA polymerases I, II, and III 7.0 kda polypeptide|DNA-directed RNA polymerase II subunit K|DNA-directed RNA polymerases I, II, and III subunit RPABC4|RNA polymerase II 7.0 kDa subunit|RNA polymerases I, II, and III subunit ABC4 |
Swissprots | Q6IBD4 P53803 |
Accessions | CAB91873 EAW91798 EAW91799 P53803 BC000806 AAH00806 BC018157 AAH18157 CR456870 CAG33151 DQ891159 ABM82085 DQ894340 ABM85266 Z47727 CAA87656 NM_005034 NP_005025 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. |
Subcellular Location | Nucleus {ECO:0000250}. |
Top Pathways | Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase |
POLR2K CRISPR/Cas9 KO Plasmid (h) - sc-417268 from Santa Cruz Biotechnology
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POLR2K HDR Plasmid (h) - sc-417268-HDR from Santa Cruz Biotechnology
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POLR2K Double Nickase Plasmid (h) - sc-417268-NIC from Santa Cruz Biotechnology
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POLR2K Double Nickase Plasmid (h2) - sc-417268-NIC-2 from Santa Cruz Biotechnology
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POLR2K CRISPR Activation Plasmid (h) - sc-417268-ACT from Santa Cruz Biotechnology
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POLR2K CRISPR Activation Plasmid (h2) - sc-417268-ACT-2 from Santa Cruz Biotechnology
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POLR2K Lentiviral Activation Particles (h) - sc-417268-LAC from Santa Cruz Biotechnology
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POLR2K Lentiviral Activation Particles (h2) - sc-417268-LAC-2 from Santa Cruz Biotechnology
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POLR2K siRNA (h) - sc-62836 from Santa Cruz Biotechnology
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POLR2K shRNA Plasmid (h) - sc-62836-SH from Santa Cruz Biotechnology
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POLR2K shRNA (h) Lentiviral Particles - sc-62836-V from Santa Cruz Biotechnology
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POLR2K RNAi - H00005440-R01 from Novus Biologicals
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MISSION® esiRNA - EHU056531 from Sigma-Aldrich
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MISSION® siRNA - SIHK1771 from Sigma-Aldrich
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MISSION® siRNA - SIHK1772 from Sigma-Aldrich
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MISSION® siRNA - SIHK1770 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17124 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17124 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05815 from Sigma-Aldrich
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POLR2K siRNA (Human) - CRH3643 from Cohesion Biosciences
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shRNA set against Human POLR2K (NM_005034.3) - SHH379508 from Creative biogene
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shRNA set against Human POLR2K(NM_005034.3) - SHR127608 from Creative biogene
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POLR2K shRNA Plasmid (Human) - CHH3643 from Cohesion Biosciences
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POLR2K miRNA 3'UTR clone - MiUTR1H-08079 from Creative biogene
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