DACT1

Gene Symbol DACT1
Entrez Gene 51339
Alt Symbol DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3
Species Human
Gene Type protein-coding
Description dishevelled-binding antagonist of beta-catenin 1
Other Description dapper antagonist of catenin 1|dapper homolog 1|dapper, antagonist of beta-catenin, homolog 1|hepatocellular carcinoma novel gene 3 protein|heptacellular carcinoma novel gene 3
Swissprots Q86TY0 A8MYJ2 Q9NYF0
Accessions EAW80742 Q9NYF0 AF251079 AAF65569 AI803159 AK299879 BAH13159 AK316164 BAH14535 AK316169 BAH14540 AK316237 BAH14608 AK316423 BAH14794 AY603415 AAT99436 BC172261 AAI72261 BC172563 AAI72563 BK000256 DAA00310 BU742074 BX161433 CAD61905 CN304224 DR001289 DR157190 XM_006720167 XP_006720230 NM_001079520 NP_001072988 NM_016651 NP_057735 NR_046093 NR_046095
Function Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway
Subcellular Location Cytoplasm. Nucleus. Cell junction, synapse {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

Dapper1 (D-4) - sc-377030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dapper1 (D-4): sc-377030. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and endothelial cells.

Dapper1 (D-19) - sc-74599 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dapper1 (D-19): sc-74599. Western blot analysis of Dapper1 expression in U-87 MG (A) and SK-N-SH (B) whole cell lysates.

Dapper1 (H-180) - sc-98366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Dact1 / Dapper homolog 1 antibody - ab51260 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
HeLa cells stained with ab51260 Dact1/Dapper homolog 1 antibody (red) at a dilution of 1/200.

Anti-Dact1 / Dapper homolog 1 antibody - ab42547 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Dact1 / Dapper homolog 1 antibody (ab42547) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.developed using the ECL techniquePerformed under reducing conditions.

Anti-DACT1 / DAPPER Antibody (aa152-168) - LS-C3315 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa32-49) - LS-C47453 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa373-386) - LS-C187896 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, AP) - LS-C255835 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, Biotin) - LS-C255838 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, APC) - LS-C255837 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, FITC) - LS-C255839 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, Azide-free, HRP) - LS-C255840 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa13-41, PE) - LS-C255843 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa20-49) - LS-C320730 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DACT1 / DAPPER Antibody (aa343-392) - LS-C145635 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DACT1 antibody LS-C145635 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-DACT1 / DAPPER Antibody (aa139-188) - LS-C146119 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DACT1 antibody LS-C146119 Western blot of 435S Cell lysate. Antibody concentration 1 ug/ml.

Anti-DACT1 / DAPPER Antibody (aa673-722) - LS-C145968 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DACT1 antibody LS-C145968 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-DACT1 / DAPPER Antibody (aa725-775) IHC-plus™ - LS-B7941 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DACT1 / DAPPER antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7941 dilution 10 ug/ml.

Anti-DACT1 / DAPPER Antibody (aa13-41) - LS-C167262 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DACT1 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Dact1 Antibody - NBP2-24768 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Dact1 Antibody [NBP2-24768] - analysis of Dapper homolog 1 in brain lysate. Lane 1 shows pre-immune sera. Lanes 2, 3 and 4 show this antibody. 5 ug/ml) and rat brain (0.5 ug/ml) lysate.

Dact1 Antibody - NBP1-85308 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Dact1 Antibody [NBP1-85308] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

Dact1 Antibody (5D8) - H00051339-M03-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D8

Rabbit Anti-Dact1/Dapper homolog 1 Polyclonal Antibody - bs-11835R from Bioss

Host Rabbit
Clonality Polyclonal
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