| Gene Symbol |
DACT1
|
| Entrez Gene |
51339
|
| Alt Symbol |
DAPPER, DAPPER1, DPR1, FRODO, HDPR1, THYEX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dishevelled-binding antagonist of beta-catenin 1
|
| Other Description |
dapper antagonist of catenin 1|dapper homolog 1|dapper, antagonist of beta-catenin, homolog 1|hepatocellular carcinoma novel gene 3 protein|heptacellular carcinoma novel gene 3
|
| Swissprots |
Q86TY0 A8MYJ2 Q9NYF0
|
| Accessions |
EAW80742 Q9NYF0 AF251079 AAF65569 AI803159 AK299879 BAH13159 AK316164 BAH14535 AK316169 BAH14540 AK316237 BAH14608 AK316423 BAH14794 AY603415 AAT99436 BC172261 AAI72261 BC172563 AAI72563 BK000256 DAA00310 BU742074 BX161433 CAD61905 CN304224 DR001289 DR157190 XM_006720167 XP_006720230 NM_001079520 NP_001072988 NM_016651 NP_057735 NR_046093 NR_046095
|
| Function |
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway
|
| Subcellular Location |
Cytoplasm. Nucleus. Cell junction, synapse {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.
|