PIK3C3

Gene Symbol	PIK3C3
Entrez Gene	5289
Alt Symbol	VPS34, Vps34
Species	Human
Gene Type	protein-coding
Description	phosphatidylinositol 3-kinase, catalytic subunit type 3
Other Description	PI3-kinase type 3|PI3K type 3|PtdIns-3-kinase type 3|phosphatidylinositol 3-kinase catalytic subunit type 3|phosphatidylinositol 3-kinase p100 subunit|phosphoinositide-3-kinase, class 3
Swissprots	Q8NEB9 Q15134
Accessions	EAX01426 Q8NEB9 AF131843 AK022653 AK090567 AK298517 BAG60721 AK308364 BC010388 BC033004 AAH33004 BC040982 BC053651 AAH53651 BI562123 CA945171 DB450556 DQ890552 ABM92169 DQ893712 ABM84638 Z46973 CAA87094 XM_011526030 XP_011524332 XM_011526031 XP_011524333 XR_935226 NM_001308020 NP_001294949 NM_002647 NP_002638
Function	Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. {ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:7628435}.
Subcellular Location	Midbody. Late endosome. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269|PubMed:7628435}.
Top Pathways	Phagosome, Tuberculosis, Inositol phosphate metabolism, Regulation of autophagy, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PI3 Kinase Class III Antibody - 3811 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

PI3 Kinase Class III (D4E2) Rabbit mAb - 3358 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D4E2

PI3 Kinase Class III (D9A5) Rabbit mAb - 4263 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D9A5

PI 3-kinase p100 (C-18) - sc-54400 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PI 3-kinase p100 (F-11) - sc-365404 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PI 3-kinase p100 (H-300) - sc-134986 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody - ab5451 from Abcam Prices $385.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody - ab101799 from Abcam Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody - ab168979 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody - ab137784 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody - ab73262 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PI 3 Kinase Class 3 antibody [EPR5301] - ab124905 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5301

Anti-PI 3 Kinase Class 3 antibody - N-terminal - ab191615 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody - LS-C18518 from LifeSpan Bioscience Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody - LS-C74962 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody - LS-C131400 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody - LS-C131402 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody - LS-C131401 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (phospho-Ser164) - LS-C158062 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (phospho-Ser282) - LS-C158063 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (phospho-Ser676) - LS-C158064 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (aa22-34) - LS-C188042 from LifeSpan Bioscience Prices $420.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (Ser164, AP) - LS-C266224 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (Internal) - LS-C141888 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIK3C3 / VPS34 Antibody (Ser164, APC) - LS-C266225 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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