KCNJ1
| Gene Symbol | KCNJ1 |
|---|---|
| Entrez Gene | 3758 |
| Alt Symbol | KIR1.1, ROMK, ROMK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 1 |
| Other Description | ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|inward rectifier K(+) channel Kir1.1|inwardly rectifying K+ channel|potassium channel, inwardly rectifying subfamily J member 1|potassium inwardly-rectifying channel, subfamily J, member 1 |
| Swissprots | P48048 B2RMR4 Q6LD67 |
| Accessions | AAC51220 AAC51221 AAC51222 EAW67721 EAW67722 EAW67723 EAW67724 EAW67725 P48048 AI795925 AK290797 BAF83486 AK308032 AK308033 AK314267 AW611934 BC063109 BC074752 AAH74752 BC136360 AAI36361 BC136361 AAI36362 BE466312 DA622270 DA629130 DB199073 S78737 AAB35012 U03884 AAA20594 U12541 AAA61712 U12542 AAA61713 U12543 AAA61714 U12544 AAA61715 U12545 AAA61716 NM_000220 NP_000211 NM_153764 NP_722448 NM_153765 NP_722449 NM_153766 NP_722450 NM_153767 NP_722451 |
| Function | In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:12684516}; Multi-pass membrane protein {ECO:0000269|PubMed:12684516}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. |
| Tissue Specificity | In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. {ECO:0000269|PubMed:7635463}. |
| Top Pathways | Aldosterone-regulated sodium reabsorption, Gastric acid secretion |
ROM-K CRISPR/Cas9 KO Plasmid (h) - sc-404241 from Santa Cruz Biotechnology
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ROM-K HDR Plasmid (h) - sc-404241-HDR from Santa Cruz Biotechnology
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ROM-K Double Nickase Plasmid (h) - sc-404241-NIC from Santa Cruz Biotechnology
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ROM-K Double Nickase Plasmid (h2) - sc-404241-NIC-2 from Santa Cruz Biotechnology
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ROM-K CRISPR Activation Plasmid (h) - sc-404241-ACT from Santa Cruz Biotechnology
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ROM-K CRISPR Activation Plasmid (h2) - sc-404241-ACT-2 from Santa Cruz Biotechnology
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ROM-K Lentiviral Activation Particles (h) - sc-404241-LAC from Santa Cruz Biotechnology
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ROM-K Lentiviral Activation Particles (h2) - sc-404241-LAC-2 from Santa Cruz Biotechnology
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ROM-K siRNA (h) - sc-42632 from Santa Cruz Biotechnology
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ROM-K shRNA Plasmid (h) - sc-42632-SH from Santa Cruz Biotechnology
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ROM-K shRNA (h) Lentiviral Particles - sc-42632-V from Santa Cruz Biotechnology
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KCNJ1 RNAi - H00003758-R05 from Novus Biologicals
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KCNJ1 RNAi - H00003758-R04 from Novus Biologicals
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KCNJ1 RNAi - H00003758-R03 from Novus Biologicals
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KCNJ1 RNAi - H00003758-R01 from Novus Biologicals
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MISSION® esiRNA - EHU061211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2549 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2549 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08320 from Sigma-Aldrich
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KCNJ1 siRNA (Human) - CRH2534 from Cohesion Biosciences
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KCNJ1 RNAi - H00003758-R02 from Novus Biologicals
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KCNJ1, siRNA - MBS8222777 from MyBioSource
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shRNA set against Human KCNJ1 (NM_000220.3) - SHH323179 from Creative biogene
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shRNA set against Human KCNJ1(NM_153764.1) - SHL189174 from Creative biogene
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Human KCNJ1 siRNA - orb263036 from Biorbyt
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