HDAC2

Gene Symbol	HDAC2
Entrez Gene	3066
Alt Symbol	HD2, RPD3, YAF1
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 2
Other Description	YY1-associated factor 1|transcriptional regulator homolog RPD3
Swissprots	Q92769 B4DL58 Q5SRI8 Q5SZ86 E1P561 B3KRS5 Q8NEH4
Accessions	EAW48252 EAW48253 EAW48254 EAW48255 Q92769 AA704179 AB209190 BAD92427 AK092156 BAG52487 AK097376 BAG53457 AK296856 BAG59420 AV719958 BC013141 BC031055 AAH31055 BC146376 AAI46377 BC148797 AAI48798 BM550464 BP201509 CN304190 CN315003 U31814 AAC50814 XM_011535786 XP_011534088 XM_011535787 XP_011534089 XM_011535788 XP_011534090 NM_001527 NP_001518 NR_033441 NR_073443
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-m
Subcellular Location	Nucleus {ECO:0000269|PubMed:24970816}. Cytoplasm {ECO:0000269|PubMed:24970816}.
Tissue Specificity	Widely expressed; lower levels in brain and lung.
Top Pathways	Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HDAC2 full length protein - ab42630 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human HDAC2 full length protein - ab101662 from Abcam Category Protein Source Baculovirus Species Human

Human HDAC2 peptide - ab16200 from Abcam Category Peptide

HDAC2 Antibody Blocking Peptide - LS-E11450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC2 Antibody Blocking Peptide - LS-E11449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC2 Antibody Blocking Peptide - LS-E11143 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC2 Antibody Blocking Peptide - LS-E10303 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Histone Deacetylase 2/HDAC2 Protein - NBP1-72399 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source Baculovirus Species Human

Histone Deacetylase 2/HDAC2 Recombinant Protein - P3732 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Species Human

HDAC2-Antibody-Center-Blocking-Peptide - BP9762c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human HDAC2 protein - orb168485 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source Hi-5 Cell.

HDAC 2 Blocking Peptide - 33R-10517 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

HDAC2 Blocking Peptide - 33R-10827 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HDAC2 protein (His tag) - 80R-1908 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source Hi-5 cells

HDAC8 protein (His tag) - 80R-2071 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source Sf-9 insect cells

HDAC2 (1-488, His-tag) - AR39094PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source High-5 Insect cells Species Human

HDAC2 (1-488, His-tag) - AR39094PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source High-5 Insect cells Species Human

HDAC2 - P3732 from Acris Antibodies Category Protein Prices $580.00 Sizes 50 µg Species Human

HDAC2 Control Peptide - AP00271CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

HDAC2 Control Peptide - SP5320CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Histone Deacetylase 2, Human Recombinant - 228-12308-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Histone Deacetylase 2 - 228-12308-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Hi-5 Cell. Species Human

Recombinant Human Histone Deacetylase 2 - 228-12308-3 from RayBiotech Category Protein Source Hi-5 Cell. Species Human

HDAC2, 1-488aa, Human,His tag, Hi-5 cell - 01-2093-2 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

HDAC2 Peptide - 7899P from ProSci Category Peptide Species Human

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