ERCC2

Gene Symbol ERCC2
Entrez Gene 2068
Alt Symbol COFS2, EM9, TFIIH, TTD, XPD
Species Human
Gene Type protein-coding
Description excision repair cross-complementation group 2
Other Description BTF2 p80|CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH 80 kDa subunit|TFIIH basal transcription factor complex 80 kDa subunit|TFIIH basal transcription factor complex helicase XPB subunit|TFIIH basal transcription factor complex helicase XPD subunit|TFIIH basal transcription factor complex helicase subunit|TFIIH p80|basic transcription factor 2 80 kDa subunit|excision repair cross-complementing rodent repair deficiency, complementation group 2|xeroderma pigmentosum complementary group D|xeroderma pigmentosum group D-complementing protein
Swissprots Q8N721 Q2YDY2 Q7KZU6 P18074 Q2TB78
Accessions AAL48323 AAM45142 EAW57341 EAW57342 P18074 AK092872 AK130849 BAC85446 AK303358 BAG64418 AL535248 BC008346 BC108255 AAI08256 BC110522 AAI10523 BC110523 AAI10524 BG719746 BM769772 BM988142 BT006883 AAP35529 BX376468 CN388234 DA409300 X52221 CAA36463 X52222 CAA36464 XM_011526611 XP_011524913 XR_935763 NM_000400 NP_000391 NM_001130867 NP_001124339
Function ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.
Subcellular Location Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633}.
Top Pathways Nucleotide excision repair, Basal transcription factors

XPD (D3Z6I) Rabbit mAb - 11963 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3Z6I
Western blot analysis of extracts from various cell lines using XPD (D3Z6I) Rabbit mAb.

TFIIH p80 (G-2) - sc-271206 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TFIIH p80 (G-2): sc-271206. Western blot analysis of TFIIH p80 expression in K-562 tissue extract.

TFIIH p80 (H-150) - sc-20696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TFIIH p80 (H-150): sc-20696. Western blot analysis of TFIIH p80 expression in K-562 nuclear extract.

TFIIH p80 (C-20) - sc-6858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TFIIH p80 (184.7) - sc-101174 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TFIIH p80 (184.7): sc-101174. Western blot analysis of TFIIH expression in HeLa nuclear extract.

Anti-XPD antibody - ab54676 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-XPD antibody - ab131005 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XPD antibody (ab131005) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-XPD antibody - ab111066 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111066 at 3.75 µg/ml staining XPD in formalin-fixed, paraffin-embedded Human Skin by Immunohistochemistry. Detection utilised biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-XPD antibody - ab56061 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XPD antibody [EPR9674] - ab150362 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9674
All lanes : Anti-XPD antibody [EPR9674] (ab150362) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : A431 cell lysateLane 4 : MCF7 cell lysateLane 5 : Raw 264.7 cell lysateLane 6 : PC12 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-XPD antibody [EPR9675] - ab167418 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9675
ab167418 showing +ve staining in Human ovarian carcinoma.

Anti-ERCC2 / XPD Antibody (N-Terminus) - LS-C112342 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ERCC2 / XPD antibody LS-C112342 Western blot of Fetal Muscle lysate.

Anti-ERCC2 / XPD Antibody - LS-C307423 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ERCC2 / XPD Antibody (clone 4G2-2A6) - LS-C197153 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G2-2A6
Western Blot analysis of ERCC2 expression in transfected 293T cell line by ERCC2 monoclonal antibody (M01), clone 4G2-2A6.Lane 1: ERCC2 transfected lysate(86.9 KDa).Lane 2: Non-transfected lysate.

Anti-ERCC2 / XPD Antibody - LS-C310269 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ERCC2 / XPD Antibody - LS-C341809 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ERCC2 / XPD Antibody IHC-plus™ - LS-B3814 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ERCC2 / XPD antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3814 concentration 3.75 ug/ml.

Anti-ERCC2 / XPD Antibody (aa710-760) - LS-C290317 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human XPD by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-XPD antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. XPD was also immunoprecipitated by rabbit anti-XPD antibody BL13160, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

Anti-ERCC2 / XPD Antibody (aa78-307, clone 4B11) - LS-C339061 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B11
Human recombinant protein fragment corresponding to amino acids 78-307 of human ERCC2 (NP_000391) produced in E.coli.

Anti-ERCC2 / XPD Antibody - LS-C331415 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell line, using ERCC2 antibody.

Anti-ERCC2 / XPD Antibody - LS-C346091 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using ERCC2 antibody. Blue: DAPI for nuclear staining.

Anti-ERCC2 / XPD Antibody - LS-C6711 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ERCC2 / XPD Antibody - LS-C6712 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ERCC2 / XPD Antibody (aa1-406) - LS-C36272 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-ERCC2 / XPD Antibody (C-Terminus) - LS-C46829 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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