ERCC2

Gene Symbol	ERCC2
Entrez Gene	2068
Alt Symbol	COFS2, EM9, TFIIH, TTD, XPD
Species	Human
Gene Type	protein-coding
Description	excision repair cross-complementation group 2
Other Description	BTF2 p80|CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH 80 kDa subunit|TFIIH basal transcription factor complex 80 kDa subunit|TFIIH basal transcription factor complex helicase XPB subunit|TFIIH basal transcription factor complex helicase XPD subunit|TFIIH basal transcription factor complex helicase subunit|TFIIH p80|basic transcription factor 2 80 kDa subunit|excision repair cross-complementing rodent repair deficiency, complementation group 2|xeroderma pigmentosum complementary group D|xeroderma pigmentosum group D-complementing protein
Swissprots	Q8N721 Q2YDY2 Q7KZU6 P18074 Q2TB78
Accessions	AAL48323 AAM45142 EAW57341 EAW57342 P18074 AK092872 AK130849 BAC85446 AK303358 BAG64418 AL535248 BC008346 BC108255 AAI08256 BC110522 AAI10523 BC110523 AAI10524 BG719746 BM769772 BM988142 BT006883 AAP35529 BX376468 CN388234 DA409300 X52221 CAA36463 X52222 CAA36464 XM_011526611 XP_011524913 XR_935763 NM_000400 NP_000391 NM_001130867 NP_001124339
Function	ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633}.
Top Pathways	Nucleotide excision repair, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XPD full length protein - ab132967 from Abcam Category Protein Source Wheat germ Species Human

Human XPD peptide - ab30639 from Abcam Category Peptide

ERCC2 / XPD Antibody Blocking Peptide - LS-E10807 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XPD Protein - H00002068-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human XPD Protein - H00002068-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ERCC2 - H00002068-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

ERCC2 - H00002068-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

ERCC2 - H00002068-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ERCC2 - H00002068-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ERCC2 fusion protein - ag1038 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ERCC2, His-tagged - ERCC2-30131TH from Creative Biomart Category Protein Source E. coli

Recombinant Human TFIIH basal transcription factor complex helicase XPD subunit(ERCC2) - CSB-YP007770HU CSB-EP007770HU CSB-BP007770HU CSB-MP007770HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TFIIH basal transcription factor complex helicase XPD subunit (ERCC2), Recombinant Protein - MBS952575 from MyBioSource Category Protein Prices $2,005.00, $2,160.00, $2,385.00, $2,500.00, $2,640.00, $2,680.00, $3,150.00, $3,295.00, $3,955.00, $4,940.00 Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 1 mg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Xeroderma Pigmentosum, Complementation Group D (XPD) - RPC013Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Xeroderma Pigmentosum, Complementation Group D (XPD) - RPC013Hu01 from Cloud-clone Category Protein Source E.coli Species Human

XPD Recombinant Protein Antigen - NBP2-38382PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ERCC2-Blocking-Peptide-C-term - BP21175a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERCC2 Peptide, Human - M34GP05034H from Creative Peptides Category Peptide Source Synthetic. Species Human

ERCC2 Recombinant Protein (OPCD00899) - OPCD00899 from Aviva Systems Biology Category Protein Source E.coli Species Human

XPD Recombinant Protein Antigen - NBP2-56327PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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