| Gene Symbol |
HEPACAM2
|
| Entrez Gene |
253012
|
| Alt Symbol |
MIKI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HEPACAM family member 2
|
| Other Description |
mitotic kinetics regulator
|
| Swissprots |
B9EG93 B4DPJ1 A8MVW5 Q6UXI0 E9PDV5 B3KTT4
|
| Accessions |
A8MVW5 AK096002 BAG53196 AK298361 BAG60603 AY358345 AAQ88711 BC046365 BC136300 AAI36301 BC136301 AAI36302 BC139906 AAI39907 DA426282 H75859 XM_011516000 XP_011514302 XM_011516001 XP_011514303 NM_001039372 NP_001034461 NM_001288804 NP_001275733 NM_001288810 NP_001275739 NM_198151 NP_937794
|
| Function |
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. {ECO:0000269|PubMed:22864114}.
|
| Subcellular Location |
Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation).
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:19358830}.
|