| Gene Symbol | LPAR6 |
|---|---|
| Entrez Gene | 10161 |
| Alt Symbol | ARWH1, HYPT8, LAH3, P2RY5, P2Y5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysophosphatidic acid receptor 6 |
| Other Description | G-protein coupled purinergic receptor P2Y5|LPA receptor 6|LPA-6|P2Y purinoceptor 5|RB intron encoded G-protein coupled receptor|oleoyl-L-alpha-lysophosphatidic acid receptor|purinergic receptor 5|purinergic receptor P2Y G protein-coupled protein 5|purinergic receptor P2Y, G-protein coupled, 5 |
| Swissprots | Q7Z3S0 O15133 A4FTW9 Q3KPF5 F2YGU4 Q7Z3S6 Q5VW44 P43657 Q53FA0 B3KVF2 |
| Accessions | AAL40065 AAN64134 EAX08796 EAX08797 P43657 AF000546 AAB62190 AK122856 BAG53764 AK123059 BAG53867 AK223389 BAD97109 BC039373 BC040850 AAH40850 BC045651 AAH45651 BC054346 BC070295 AAH70295 BC106756 AAI06757 BF950635 BF951153 BQ006077 BX537392 CAD97634 BX537438 CAD97680 BX537445 CAD97687 BX647109 EU831916 ACE87357 EU832010 ACE86673 HQ995530 ADZ31975 JF810890 AEP43757 NM_001162497 NP_001155969 NM_001162498 NP_001155970 NM_005767 NP_005758 |
| Function | Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. {ECO:0000269|PubMed:18297070}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18297070}; Multi-pass membrane protein {ECO:0000269|PubMed:18297070}. |
| Tissue Specificity | Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. {ECO:0000269|PubMed:11004484, ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:18297072}. |
| Top Pathways | PI3K-Akt signaling pathway, Neuroactive ligand-receptor interaction |
P2Y5 CRISPR/Cas9 KO Plasmid (h) - sc-405189 from Santa Cruz Biotechnology
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P2Y5 HDR Plasmid (h) - sc-405189-HDR from Santa Cruz Biotechnology
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P2Y5 Double Nickase Plasmid (h) - sc-405189-NIC from Santa Cruz Biotechnology
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P2Y5 Double Nickase Plasmid (h2) - sc-405189-NIC-2 from Santa Cruz Biotechnology
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P2Y5 CRISPR Activation Plasmid (h) - sc-405189-ACT from Santa Cruz Biotechnology
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P2Y5 CRISPR Activation Plasmid (h2) - sc-405189-ACT-2 from Santa Cruz Biotechnology
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P2Y5 Lentiviral Activation Particles (h) - sc-405189-LAC from Santa Cruz Biotechnology
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P2Y5 Lentiviral Activation Particles (h2) - sc-405189-LAC-2 from Santa Cruz Biotechnology
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P2Y5 siRNA (h) - sc-42583 from Santa Cruz Biotechnology
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P2Y5 shRNA Plasmid (h) - sc-42583-SH from Santa Cruz Biotechnology
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P2Y5 shRNA (h) Lentiviral Particles - sc-42583-V from Santa Cruz Biotechnology
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LPAR6/P2RY5 RNAi - H00010161-R02 from Novus Biologicals
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MISSION® esiRNA - EHU039331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12646 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12646 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04344 from Sigma-Aldrich
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LPAR6 siRNA (Human) - CRH6860 from Cohesion Biosciences
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shRNA set against Human AR (NM_005767.5) - SHH238966 from Creative biogene
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P2Y5 CRISPR/Cas9 KO Plasmid (h2) - sc-405189-KO-2 from Santa Cruz Biotechnology
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P2Y5 HDR Plasmid (h2) - sc-405189-HDR-2 from Santa Cruz Biotechnology
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LPAR6 shRNA Plasmid (Human) - CHH6860 from Cohesion Biosciences
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LPAR6 miRNA 3'UTR clone - MiUTR3H-10503 from Creative biogene
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LPAR6 miRNA 3'UTR clone - MiUTR3H-10504 from Creative biogene
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LPAR6 miRNA 3'UTR clone - MiUTR3H-10505 from Creative biogene
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