Gene Symbol | TMEM97 |
---|---|
Entrez Gene | 27346 |
Alt Symbol | MAC30 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 97 |
Other Description | - |
Swissprots | B4DS02 Q07823 Q5BJF2 |
Accessions | EAW51067 EAW51068 EAW51069 Q5BJF2 AK293331 BAG56847 AK299511 BAG61464 AK307678 BC017362 BC045655 AAH45655 BC091504 AAH91504 CA441136 DA410183 L19183 AAA16188 XM_005257965 XP_005258022 NM_014573 NP_055388 |
Function | Plays a role as a regulator of cellular cholesterol homeostasis. {ECO:0000269|PubMed:19583955}. |
Subcellular Location | Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Note=Localized in sterol- depleted cells at cell membrane and in lysosomes. |
Tissue Specificity | Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells and meningioma cancers. Expressed in ovarian cancer; expression is reduced relative to OSE cells. {ECO:0000269|PubMed:15375745, ECO:0000269|PubMed:18070364, ECO:0000269|PubMed:7694637}. |