| Gene Symbol |
C6orf25
|
| Entrez Gene |
80739
|
| Alt Symbol |
G6b, NG31
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 6 open reading frame 25
|
| Other Description |
G6B|immunoglobulin receptor|protein G6b
|
| Swissprots |
Q96A87 B0V024 Q96A91 A2BEZ1 A2BEZ4 Q96A90 Q96A86 Q14CK2 Q96A88 Q96A89 A2BEZ3 A2BEZ2 B0UXC8 B0V026 A2BEZ5 B0UXC4 B0UXC7 O95866
|
| Accessions |
AAD18075 BAB63378 CAB46080 EAX03492 EAX03493 EAX03494 EAX03495 EAX03496 EAX03497 EAX03498 EAX03499 O95866 AJ292259 CAC83497 AJ292260 CAC83496 AJ292261 CAC83498 AJ292262 CAC83502 AJ292263 CAC83499 AJ292264 CAC83500 AJ292265 CAC83501 AK092392 BAG52544 BC111842 AAI11843 BC113719 AAI13720 BC113721 AAI13722 BC143850 AAI43851 BU681844 HQ258117 ADR82871 XM_011514920 XP_011513222 XM_011514921 XP_011513223 XM_011547318 XP_011545620 XM_011547319 XP_011545621 XM_011547719 XP_011546021 XM_011547720 XP_011546022 XM_011548105 XP_011546407 XM_011548106 XP_011546408 XM_011548304 XP_011546606 XM_011548305 XP_011546607 XM_011548306 XP_011546608 XM_011548489 XP_011546791 XM_011548490 XP_011546792 NM_025260 NP_079536 NM_138272 NP_612116 NM_138273 NP_612117 NM_138274 NP_612118 NM_138275 NP_612119 NM_138277 NP_612121 NM_138276
|
| Function |
Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart. {ECO:0000269|PubMed:17311996}.
|
| Subcellular Location |
Isoform B: Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets. {ECO:0000269|PubMed:11544253, ECO:0000269|PubMed:17311996}.
|
