| Gene Symbol | CYP2F1 |
|---|---|
| Entrez Gene | 1572 |
| Alt Symbol | C2F1, CYP2F |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 2, subfamily F, polypeptide 1 |
| Other Description | CYPIIF1|cytochrome P450 2F1|cytochrome P450, subfamily IIF, polypeptide 1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
| Swissprots | A7KAU6 Q8WWJ2 A7KAV0 P24903 A7KAU9 A7KAU8 A7KAU7 Q32MN5 |
| Accessions | AAL69652 ABO41974 ABO41975 ABO41976 ABO41977 ABO41978 ABO41979 ABO41980 EAW57017 EAW57018 P24903 AK296884 BAG59445 AK298082 BAG60369 AK316498 BAH14869 BC109056 AAI09057 BC109057 J02906 AAA52156 XM_006723053 XP_006723116 XM_011526551 XP_011524853 XM_011526552 XP_011524854 XM_011526553 XP_011524855 XM_011526554 XP_011524856 XM_011526555 XP_011524857 XR_430190 XR_935755 XR_935756 NM_000774 NP_000765 |
| Function | May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3- methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. {ECO:0000269|PubMed:1974816}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305|PubMed:10383923}; Peripheral membrane protein {ECO:0000305|PubMed:10383923}. Microsome membrane {ECO:0000269|PubMed:10383923}; Peripheral membrane protein {ECO:0000269|PubMed:10383923}. |
| Tissue Specificity | Expressed in lung. Rarely detected in liver and placenta. {ECO:0000269|PubMed:1974816, ECO:0000269|PubMed:8619884}. |
| Top Pathways | Metabolism of xenobiotics by cytochrome P450 |