XRCC5

Gene Symbol	XRCC5
Entrez Gene	7520
Alt Symbol	KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Other Description	86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|TLAA|X-ray repair cross-complementing protein 5|lupus Ku autoantigen protein p86|nuclear factor IV|thyroid-lupus autoantigen
Swissprots	Q9UCQ0 Q4VBQ5 A8K3X5 Q9UCQ1 P13010 Q53HH7 Q7M4N0 Q0Z7V0
Accessions	AAC52087 AAD14875 AAY14659 AAY24231 ABG46942 CBX87168 EAW70562 EAW70563 P13010 AK026166 AK096408 AK222603 BAD96323 AK290740 BAF83429 BC019027 AAH19027 BC095442 AAH95442 BG717693 BP375944 BU184024 DQ892660 ABM83586 DQ895925 ABM86851 J04977 AAA59475 M30938 AAA36154 X57500 CAA40736 NM_021141 NP_066964
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'- deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-el
Subcellular Location	Nucleus. Nucleus, nucleolus. Chromosome.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-Ku80 Antibody, Affinity Purified - PLA0264 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human XRCC5 / Ku80 ELISA Kit (Cell-Based ELISA) - LS-F2988 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human Phospho-XRCC5 / Ku80 (Thr714) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1151 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Human XRCC5 / Ku80 ELISA Kit (Cell-Based ELISA) - LS-F2114 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human XRCC5 / Ku80 ELISA Kit (Sandwich ELISA) - LS-F9057 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse XRCC5 / Ku80 ELISA Kit (Sandwich ELISA) - LS-F9058 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.072 ng/ml Range 0.156-10 ng/ml

Ku86, Human, ELISA Kit - E01K0080 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/mL,

X-Ray Repair Cross Complementing 5 (XRCC5), Human, ELISA Kit - SED013Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

Ku80/XRCC5 Colorimetric Cell-Based ELISA Kit - CB5412 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ku70/80 Colorimetric Cell-Based ELISA - CB5751 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ku80/XRCC5 (Phospho-Thr714) Colorimetric Cell-Based ELISA Kit - CBP1136 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ku86, ELISA Kit - MBS755211 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749859 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749104 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS745281 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749397 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS750424 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

ku86, ELISA Kit - MBS754105 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS753347 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749007 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749026 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS749046 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ku86, ELISA Kit - MBS753406 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) , ELISA Kit - MBS9340932 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-ray repair cross-complementing protein 5, ELISA Kit - MBS281325 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more