| Gene Symbol |
Sostdc1
|
| Entrez Gene |
266803
|
| Alt Symbol |
Usag1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
sclerostin domain containing 1
|
| Other Description |
USAG-1|sclerostin domain-containing protein 1|uterine sensitization-associated gene 1 protein|wnt-signaling modulator
|
| Swissprots |
Q8CJA4 Q642G2
|
| Accessions |
EDM03317 EDM03318 Q642G2 AF411056 AAN45848 BC081710 AAH81710 FQ213516 NM_153737 NP_714959
|
| Function |
Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. {ECO:0000250, ECO:0000269|PubMed:12390898, ECO:0000269|PubMed:15373764}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:15373764}.
|
| Tissue Specificity |
Highly expressed within the maximally sensitized/receptive endometrium. Weakly expressed in brain, kidney and the female reproductive tract. Expressed in the dermal papilla (DP) and at high level in the precortex of both anagen vibrissae and pelage follicles. Dynymic expression during the hair cycle. {ECO:0000269|PubMed:12390898, ECO:0000269|PubMed:15373764}.
|