Gene Symbol | Sostdc1 |
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Entrez Gene | 266803 |
Alt Symbol | Usag1 |
Species | Rat |
Gene Type | protein-coding |
Description | sclerostin domain containing 1 |
Other Description | USAG-1|sclerostin domain-containing protein 1|uterine sensitization-associated gene 1 protein|wnt-signaling modulator |
Swissprots | Q8CJA4 Q642G2 |
Accessions | EDM03317 EDM03318 Q642G2 AF411056 AAN45848 BC081710 AAH81710 FQ213516 NM_153737 NP_714959 |
Function | Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. {ECO:0000250, ECO:0000269|PubMed:12390898, ECO:0000269|PubMed:15373764}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:15373764}. |
Tissue Specificity | Highly expressed within the maximally sensitized/receptive endometrium. Weakly expressed in brain, kidney and the female reproductive tract. Expressed in the dermal papilla (DP) and at high level in the precortex of both anagen vibrissae and pelage follicles. Dynymic expression during the hair cycle. {ECO:0000269|PubMed:12390898, ECO:0000269|PubMed:15373764}. |
SOSTDC1 siRNA (r) - sc-270426 from Santa Cruz Biotechnology
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SOSTDC1 shRNA Plasmid (r) - sc-270426-SH from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN63328 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND63328 from Sigma-Aldrich
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SOSTDC1 siRNA (Rat) - CRR3770 from Cohesion Biosciences
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SOSTDC1 - MBS8211916 from MyBioSource
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shRNA set against Rat SOSTDC1 (NM_153737.1) - SHH415252 from Creative biogene
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shRNA set against Rat Sostdc1(NM_153737.1) - SHL016968 from Creative biogene
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SOSTDC1 shRNA Plasmid (Rat) - CHR3770 from Cohesion Biosciences
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SOSTDC1 miRNA 3'UTR clone - MiUTR1R-07618 from Creative biogene
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