Gene Symbol | CDKN3 |
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Entrez Gene | 1033 |
Alt Symbol | CDI1, CIP2, KAP, KAP1 |
Species | Human |
Gene Type | protein-coding |
Description | cyclin-dependent kinase inhibitor 3 |
Other Description | CDK2-associated dual specificity phosphatase|CDK2-associated dual-specificity phosphatase|Cdk-associated protein phosphatase|cyclin-dependent kinase interacting protein 2|cyclin-dependent kinase interactor 1|cyclin-dependent kinase-interacting protein 2|kinase associated phosphatase|kinase-associated phosphatase |
Swissprots | Q9BY36 Q99585 Q9C051 Q9C053 Q9C047 Q9C042 Q9C049 Q9BPW7 Q5U0M4 Q9C046 Q53ZU6 Q6P1N8 Q16667 |
Accessions | AAN86348 EAW80632 EAW80633 EAW80634 Q16667 AF213033 AAK06365 AF213034 AAK06366 AF213035 AAK06367 AF213036 AAK06368 AF213037 AAK06369 AF213038 AAK06370 AF213039 AAK06371 AF213040 AAK06372 AF213041 AAK06373 AF213042 AAK06374 AF213043 AF213044 AAK06375 AF213045 AAK06376 AF213046 AAK06377 AF213047 AAK06378 AF213048 AAK06379 AF213049 AAK06380 AF213050 AAK06381 AF213051 AAK06382 AF213052 AAK06383 AF213053 AAK06384 AK098653 AK293265 BAH11478 AY257474 AAP13062 AY257475 AAP13063 AY257476 AAP13064 AY257477 AAP13065 AY257478 AAP13066 AY257479 AAP13067 BC064965 AAH64965 BC103633 AAI03634 BT019451 AAV38258 CR407666 CAG28594 EF560750 ABQ59060 L25876 AAA60222 L27711 AAA66496 U02681 AAC04932 XM_011536353 XP_011534655 NM_001130851 NP_001124323 NM_005192 NP_005183 |
Function | May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000269|PubMed:10669749}. |
CDKN3 CRISPR/Cas9 KO Plasmid (h) - sc-403243 from Santa Cruz Biotechnology
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CDKN3 HDR Plasmid (h) - sc-403243-HDR from Santa Cruz Biotechnology
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CDKN3 Double Nickase Plasmid (h) - sc-403243-NIC from Santa Cruz Biotechnology
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CDKN3 Double Nickase Plasmid (h2) - sc-403243-NIC-2 from Santa Cruz Biotechnology
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CDKN3 CRISPR Activation Plasmid (h) - sc-403243-ACT from Santa Cruz Biotechnology
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CDKN3 CRISPR Activation Plasmid (h2) - sc-403243-ACT-2 from Santa Cruz Biotechnology
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CDKN3 Lentiviral Activation Particles (h) - sc-403243-LAC from Santa Cruz Biotechnology
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CDKN3 Lentiviral Activation Particles (h2) - sc-403243-LAC-2 from Santa Cruz Biotechnology
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CDKN3 siRNA (h) - sc-43877 from Santa Cruz Biotechnology
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CDKN3 shRNA Plasmid (h) - sc-43877-SH from Santa Cruz Biotechnology
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CDKN3 shRNA (h) Lentiviral Particles - sc-43877-V from Santa Cruz Biotechnology
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CDKN3 RNAi - H00001033-R01 from Novus Biologicals
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MISSION® esiRNA - EHU060331 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0064 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0065 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0066 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5869 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5869 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00547 from Sigma-Aldrich
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CDKN3 siRNA (Human) - CRH0746 from Cohesion Biosciences
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CDKN3 - MBS8200397 from MyBioSource
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shRNA set against Human CDKN3 (NM_005192.3) - SHH260917 from Creative biogene
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Human CDKN3 siRNA - orb261248 from Biorbyt
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CDKN3 shRNA Plasmid (Human) - CHH0746 from Cohesion Biosciences
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CDKN3 miRNA 3'UTR clone - MiUTR3H-00576 from Creative biogene
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