SLIT1

Gene Symbol	SLIT1
Entrez Gene	6585
Alt Symbol	MEGF4, SLIL1, SLIT-1, SLIT3
Species	Human
Gene Type	protein-coding
Description	slit homolog 1 (Drosophila)
Other Description	multiple EGF-like domains protein 4\|multiple epidermal growth factor-like domains protein 4\|slit homolog 1 protein
Swissprots	Q9UIL7 Q8WWZ2 Q5T0V1 O75093
Accessions	EAW49956 EAW49957 EAW49958 EAW49959 O75093 AB011537 BAA32465 AB017167 BAA35184 AY029183 AAK31796 BC028105 BC139909 BC146761 AAI46762 BC146851 AAI46852 CD671648 NM_003061 NP_003052
Function	Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. {ECO:0000269\|PubMed:9813312}.
Top Pathways	Axon guidance

Slit1 (G-4) - sc-376756 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Slit1 (G-4): sc-376756. Western blot analysis of Slit1 expression in rat brain tissue extract.

Slit1 (H-137) - sc-28944 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Slit1 (H-137): sc-28944. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

Slit1 (G-17) - sc-26597 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Slit1 (E-16) - sc-16616 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Slit1 (N-14) - sc-31590 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Slit1 antibody - ab129345 from Abcam

Prices	$384.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab129345 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab129345 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Slit1 antibody - ab88491 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Slit1 antibody (ab88491) at 1/200 dilutionLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : HEK293 cells expressing mSlit1-mycLane 3 : HEK293 cells expressing hSlit2-mycLane 4 : HEK293 cells expressing hSlit3-mycLysates/proteins at 30 µg per lane.SecondaryHRP Anti-Rabbit at 1/20000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Slit1 antibody [EP5796(N)] - ab183704 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP5796(N)

Anti-Slit1 antibody [EP5796(N)] (ab183704) at 1/1000 dilution + SH-SY5Y cell lysate at 10 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-Slit1 antibody [EP5797(2)] - ab151724 from Abcam

Prices	$378.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP5797(2)

Anti-Slit1 antibody [EP5797(2)] (ab151724) at 1/1000 dilution + Human fetal brain lysate at 10 µgSecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SLIT1 Antibody (aa345-623) - LS-C296456 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant SLIT1 / SLIT-1.

Anti-SLIT1 Antibody (aa3-211) - LS-C296457 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa345-623, Biotin) - LS-C299606 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa3-112) - LS-C296458 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa3-211, Biotin) - LS-C299608 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa308-512) - LS-C296460 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa3-112, Biotin) - LS-C299611 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa647-835, Biotin) - LS-C300075 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa611-791) - LS-C296459 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa611-791, Biotin) - LS-C300242 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa308-512, Biotin) - LS-C300243 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa603-773, Biotin) - LS-C300245 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa308-512, FITC) - LS-C302011 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa611-791, FITC) - LS-C302010 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa603-773, FITC) - LS-C302012 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLIT1 Antibody (aa647-835) - LS-C296461 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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