Gene Symbol | CMTR1 |
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Entrez Gene | 23070 |
Alt Symbol | FTSJD2, KIAA0082, MTr1, hMTr1 |
Species | Human |
Gene Type | protein-coding |
Description | cap methyltransferase 1 |
Other Description | FtsJ methyltransferase domain containing 2|ISG95|S-adenosyl-L-methionine-dependent methyltransferase FTSJD2|cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1|cap1 2'O-ribose methyltransferase 1|ftsJ methyltransferase domain-containing protein 2|interferon-stimulated gene 95 kDa protein |
Swissprots | Q14670 A8K949 Q8N1G2 Q96FJ9 |
Accessions | EAX03946 Q8N1G2 AK000348 AK025809 AK124393 AK292564 BAF85253 BC010731 AAH10731 BC031890 AAH31890 D43949 BAA07893 DA508836 XM_005248955 XP_005249012 XM_006715028 XP_006715091 XR_926121 NM_015050 NP_055865 |
Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:21310715}. |
FTSJD2 CRISPR/Cas9 KO Plasmid (h) - sc-409236 from Santa Cruz Biotechnology
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FTSJD2 HDR Plasmid (h) - sc-409236-HDR from Santa Cruz Biotechnology
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FTSJD2 Double Nickase Plasmid (h) - sc-409236-NIC from Santa Cruz Biotechnology
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FTSJD2 Double Nickase Plasmid (h2) - sc-409236-NIC-2 from Santa Cruz Biotechnology
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FTSJD2 CRISPR Activation Plasmid (h) - sc-409236-ACT from Santa Cruz Biotechnology
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FTSJD2 CRISPR Activation Plasmid (h2) - sc-409236-ACT-2 from Santa Cruz Biotechnology
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FTSJD2 Lentiviral Activation Particles (h) - sc-409236-LAC from Santa Cruz Biotechnology
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FTSJD2 Lentiviral Activation Particles (h2) - sc-409236-LAC-2 from Santa Cruz Biotechnology
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FTSJD2 siRNA (h) - sc-95433 from Santa Cruz Biotechnology
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FTSJD2 shRNA Plasmid (h) - sc-95433-SH from Santa Cruz Biotechnology
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FTSJD2 shRNA (h) Lentiviral Particles - sc-95433-V from Santa Cruz Biotechnology
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FTSJD2 RNAi - H00023070-R01 from Novus Biologicals
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MISSION® esiRNA - EHU039961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8987 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8987 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09138 from Sigma-Aldrich
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CMTR1 siRNA (Human) - CRH7975 from Cohesion Biosciences
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CMTR1 - MBS8212469 from MyBioSource
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shRNA set against Human FTSJD2 (NM_015050.2) - SHH297609 from Creative biogene
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CMTR1 shRNA Plasmid (Human) - CHH7975 from Cohesion Biosciences
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FTSJD2 miRNA 3'UTR clone - MiUTR3H-14973 from Creative biogene
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