AJUBA

Gene Symbol	AJUBA
Entrez Gene	84962
Alt Symbol	JUB
Species	Human
Gene Type	protein-coding
Description	ajuba LIM protein
Other Description	LIM domain-containing protein ajuba|jub, ajuba homolog
Swissprots	D3DS37 Q96IF1 A8MX18
Accessions	EAW66204 EAW66205 Q96IF1 AA909473 AK025567 AK096128 BAG53217 AW615335 AY169959 AAO37641 BC007580 AAH07580 BC016733 BC034968 AAH34968 BU543883 BX109281 CB105505 DQ893513 ABM84439 DQ896486 ABM87485 NM_001289097 NP_001276026 NM_032876 NP_116265 NM_198086 NP_932352
Function	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin tr
Subcellular Location	Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JUB 293T Cell Transient Overexpression Lysate(Denatured) - H00084962-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

AJUBA overexpression lysate - LY405073 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AJUBA overexpression lysate - LY409908 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

JUB 293 Cell Lysate - 403522 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Xenopus

JUB 293 Cell Lysate - 405124 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Xenopus

Ajuba Overexpression Lysate (Native) - NBL1-12114 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ajuba Overexpression Lysate (Native) - NBL1-12115 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

JUB Over-expression Lysate Product - GWB-E30AC2 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

JUB Over-expression Lysate Product - GWB-CD07F2 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Ajuba Overexpression Lysate (Denatured) - H00084962-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human AJUBA Knockdown Stable Cell Line - CSC-DC000422 from Creative biogene Category Cell Line Species Human

Human AJUBA Knockout Cell Line-HeLa - CSC-RT1560 from Creative biogene Category Cell Line Species Human

AJUBA KO Cell Lysate-HeLa - CLKO-1407 from Creative biogene Category Cell Lysate

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