| Gene Symbol |
C4BPB
|
| Entrez Gene |
725
|
| Alt Symbol |
C4BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 4 binding protein, beta
|
| Other Description |
C4b-binding protein beta chain
|
| Swissprots |
Q9BS25 D3DT81 Q5VVR0 P20851 A5JYP8
|
| Accessions |
ABQ52216 EAW93504 EAW93505 EAW93506 P20851 AK092427 AK293379 BAG56891 AK315137 BC005378 AAH05378 BG568018 BM987840 H63461 JF432656 ADZ15873 L11245 AAA35616 M29964 AAB59520 XM_005273253 XP_005273310 XM_005273254 XP_005273311 XM_005273255 XP_005273312 NM_000716 NP_000707 NM_001017364 NP_001017364 NM_001017365 NP_001017365 NM_001017366 NP_001017366 NM_001017367 NP_001017367
|
| Function |
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades, Pertussis
|
